[18]F-氟胆碱正电子发射计算机断层扫描和[18]F-氟脱氧葡萄糖正电子发射计算机断层扫描在评估乳腺癌表型中的实用性:一项试点研究。

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Mohd Hazeman Zakaria, Shazreen Shaharudin, Fathinul Fikri Ahmad Saad
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引用次数: 0

摘要

[18]F氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描([18]F FDG PET-CT)标记物对乳腺癌的作用已得到公认。鉴于其在定位 FDG 阴性恶性肿瘤方面的局限性,[18]F-氟胆碱([18]-FCH)的表达可能有助于提高评估乳腺癌的整体准确性。本研究确定了[18]-FCH PET CT 作为评估乳腺癌表型的潜在标记物的潜力。我们连续招募了经活检证实的乳腺癌患者,他们在接受[18]F-FDG PET-CT成像后又接受了[18]F-FCH PET-CT成像。受试者被分为人类表皮生长因子受体 2 (HER2) 阴性基因型和 HER2 阳性基因型。最大标准化摄取值(SUVmax;克/分升)用于预测两组变量。根据 EORTC 生活质量问卷(QLQ)得出的总体健康状况(GHS)评分用于评估队列受试者在 6、12 和 24 个月时的结果。21名女性患者的平均年龄为(54.48 ± 12.17)岁。18名患者的组织学检查结果为浸润性导管癌(18/21;85.8%),其中11人(52.4%)的基因型为HER2阴性。乳腺病变中[18]-FCH-PET/CT的敏感性和特异性分别为40%和68.8%,而[18]FDGPET/CT的敏感性和特异性分别为33.3%和66.7%。HER阴性组与HER2阳性组的[18]F-FCH SUVmax (g/dL) 有明显差异(1.99 g/dL vs. 0.2 g/dL; P < .05)。[18]F-FCH的高SUVmax (g/dL) 预测了HER阴性基因型的临界值为0.75 (P < .05)。与低[18]F-FCH相比,高[18]F-FCH在6个月时的GHS参数评分明显较差(平均SUVmax分别为8.06 vs. 5.40;P < .05)。[18]F-FCH PET-CT 是定位和预测侵袭性乳腺癌表型的潜在标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Utility of [18]F-Fluorocholine Positron Emission Computed Tomography and [18]F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in Evaluating Breast Cancer Phenotypes: A Pilot Study.

The utility of the [18]F fluorodeoxyglucose positron emission tomography-computed tomography ([18]F FDG PET-CT) marker for breast cancer is well established. Given its limitations in localizing FDG-negative malignant tumors, the expression of [18]F-fluorocholine ([18]-FCH) may potentially be helpful to improve the overall accuracy in evaluating breast cancer. This study determined the potential of [18]- FCH PET CT as a potential marker in assessing breast cancer phenotypes. We recruited consecutive patients with biopsy-proven breast carcinoma who underwent [18] F-FCH PET-CT following the [18]F-FDG PET-CT imaging. The subjects were dichotomized into human epidermal growth factor receptor 2 (HER2)-negative and HER2-positive genotypes. The maximum standardized uptake value (SUVmax; g/dL) was used to predict the two groups of variables. Global health status (GHS) score based on the EORTC quality of life questionnaire (QLQ) was used to evaluate the outcome of the cohort subjects at 6, 12, and 24 months. There were 21 females with a mean age of 54.48 ± 12.17 years. Eighteen patients had invasive ductal carcinoma (18/21;85.8%) on histology, with 11 (52.4%) were HER2-negative genotype. There was higher sensitivity and specificity of [18]-FCH-PET/CT in breast lesions at 40% and 68.8% compared to [18]FDGPET/CT with 33.3% and 66.7%, respectively. There were significant differences between [18]F-FCH SUVmax (g/dL) of the HER-negative as compared to the HER2- positive group (1.99 g/dL vs. 0.2 g/dL; P < .05). High SUVmax (g/dL) of [18]F-FCH had predicted the HER-negative genotype at the cutoff value of 0.75 (P < .05). High [18]F-FCH showed significantly poor scoring of GHS parameters compared to low FCH at 6 months (mean SUVmax 8.06 vs. 5.40 respectively; P < .05). [18]F-FCH PET-CT is a potential marker in localizing and predicting aggressive breast carcinoma phenotypes.

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来源期刊
Eurasian Journal of Medicine
Eurasian Journal of Medicine Medicine-Medicine (all)
CiteScore
1.90
自引率
6.70%
发文量
59
审稿时长
16 weeks
期刊介绍: Eurasian Journal of Medicine (Eurasian J Med) is an international, scientific, open access periodical published by independent, unbiased, and triple-blinded peer-review principles. The journal is the official publication of Atatürk University School of Medicine and published triannually in February, June, and October. The publication language of the journal is English. The aim of the Eurasian Journal of Medicine is to publish original research papers of the highest scientific and clinical value in all medical fields. The Eurasian J Med also includes reviews, editorial short notes and letters to the editor that either as a comment related to recently published articles in our journal or as a case report. The target audience of the journal includes researchers, physicians and healthcare professionals who are interested or working in in all medical disciplines.
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