转移到皮肤的肾上腺皮质癌:病例报告和罕见肿瘤综述。

IF 1.1 4区 医学 Q4 DERMATOLOGY
American Journal of Dermatopathology Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI:10.1097/DAD.0000000000002816
Efrain Lee-Diaz, Carlo Contreras, Jose A Plaza
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引用次数: 0

摘要

摘要:肾上腺皮质癌是一种非常罕见的肿瘤疾病,预后较差,初发时通常会转移至肺、肝、局部淋巴结和腹膜。然而,皮肤转移非常罕见,即使在疾病晚期也鲜有报道。我们报告了一例 41 岁男性患者的病例,该患者已知右侧肾上腺皮质癌病史,并伴有手臂肿块。组织病理切片显示,真皮和皮下脂肪中有多结节性坏死的恶性肿瘤,由非典型上皮样细胞组成,具有丰富的颗粒状胞质和多形性水泡核,核内常有包涵体和非典型有丝分裂。免疫组化染色显示,肿瘤细胞的突触素和抑制素呈强阳性,Melan-A仅呈局部阳性,而AE1/AE3呈阴性。组织病理学特征和免疫组化特征证实了肾上腺皮质转移癌的诊断。这种肿瘤的诊断可能比较困难(尤其是在没有提供临床数据的情况下),免疫组化检查通常有助于将这种肿瘤与其他具有类似细胞形态学特征的肿瘤区分开来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metastatic Adrenocortical Carcinoma to the Skin: A Case Report and Review of This Unusual Neoplasm.

Abstract: Adrenocortical carcinoma is a very rare oncologic condition with poor prognosis that usually metastasizes to the lungs, liver, local lymph nodes, and peritoneum at initial presentation. However, skin metastasis is very uncommon and has rarely been reported even in advanced stages of the disease. We present a case of a 41-year-old man with a known history of adrenocortical carcinoma of the right adrenal gland that presented with an arm mass. The histopathologic sections showed a multinodular necrotic malignant neoplasm in dermis and subcutaneous fat composed of atypical epithelioid cells with ample granular cytoplasm and pleomorphic vesicular nuclei with frequent intranuclear inclusions and atypical mitoses. The immunohistochemical stains showed tumor cells that were strongly positive for synaptophysin and inhibin, only focally positive for Melan-A, and negative for AE1/AE3. The histopathologic features and the immunohistochemical profile confirmed the diagnosis of metastatic carcinoma consistent with adrenal cortical origin. The diagnosis can be difficult (especially when no clinical data are provided), and an immunohistochemical battery is often useful in distinguishing this tumor from other tumors with similar cytomorphological features.

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来源期刊
CiteScore
1.80
自引率
9.10%
发文量
453
审稿时长
3 months
期刊介绍: The American Journal of Dermatopathology offers outstanding coverage of the latest diagnostic approaches and laboratory techniques, as well as insights into contemporary social, legal, and ethical concerns. Each issue features review articles on clinical, technical, and basic science advances and illuminating, detailed case reports. With the The American Journal of Dermatopathology you''ll be able to: -Incorporate step-by-step coverage of new or difficult-to-diagnose conditions from their earliest histopathologic signs to confirmatory immunohistochemical and molecular studies. -Apply the latest basic science findings and clinical approaches to your work right away. -Tap into the skills and expertise of your peers and colleagues the world over peer-reviewed original articles, "Extraordinary cases reports", coverage of practical guidelines, and graphic presentations. -Expand your horizons through the Journal''s idea-generating forum for debating controversial issues and learning from preeminent researchers and clinicians
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