Aquaporin 3 在犬皮脂腺的基底细胞中表达。

IF 1.1 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Veterinary Medical Science Pub Date : 2024-10-01 Epub Date: 2024-08-15 DOI:10.1292/jvms.24-0188

Hiroko Sonoda, Yoshiki Taniguchi, Naruki Fujimoto, Yoshiki Higashijima, Toshiyuki Matsuzaki, Takuya Hirai, Teruo Itoh, Kazuyuki Uchida, Masahiro Ikeda

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引用次数: 0

摘要

过去 20 年来，水蒸发蛋白（AQPs）在肿瘤生物学中的作用一直备受关注。然而，AQPs 在犬皮脂腺肿瘤中的表达谱仍不清楚。本研究旨在阐明皮脂腺腺瘤和皮脂腺上皮瘤中 AQP1、3、5 的表达情况。在这些 AQPs 中，只有 AQP3 在正常组织和两种肿瘤类型中均有表达，且仅位于未分化的皮脂腺细胞（基底细胞）中。细胞增殖标记物 Ki67 仅在两种肿瘤类型中包括基底细胞的区域被检测到。这些发现表明，AQP3 有助于明确皮脂腺肿瘤的起源，而且 AQP3 可能与皮脂腺的发育有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Aquaporin 3 is expressed in the basaloid cells of canine sebaceous glands.

The role of aquaporin proteins (AQPs) in tumor biology has attracted attention over the past 20 years. However, the expression profiles of AQPs in canine sebaceous gland tumors remain obscure. This study was performed to clarify the expression of AQP1, 3, 5, the most studied AQPs in tumor biology, in sebaceous adenoma and sebaceous epithelioma. Among these AQPs, only AQP3 was expressed in normal tissue and both tumor types and located to only undifferentiated sebocytes (basaloid cells). A cellular proliferation marker, Ki-67, was detected only in the area including basaloid cells in both tumor types. These findings suggest that AQP3 is useful for clarifying the origin of sebaceous gland tumors, and that AQP3 may be related to sebaceous gland development.

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来源期刊

Journal of Veterinary Medical Science 农林科学-兽医学

CiteScore

2.30

自引率

8.30%

发文量

230

审稿时长

9-18 weeks

期刊介绍： JVMS is a peer-reviewed journal and publishes a variety of papers on veterinary science from basic research to applied science and clinical research. JVMS is published monthly and consists of twelve issues per year. Papers are from the areas of anatomy, physiology, pharmacology, toxicology, pathology, immunology, microbiology, virology, parasitology, internal medicine, surgery, clinical pathology, theriogenology, avian disease, public health, ethology, and laboratory animal science. Although JVMS has played a role in publishing the scientific achievements of Japanese researchers and clinicians for many years, it now also accepts papers submitted from all over the world.