英国国家卫生服务乳腺筛查计划诊断规程在可触及乳腺肿块病例的细针抽吸细胞学与细胞块制备中的实用性:一种可靠、快速、准确的诊断方法,用于评估与组织病理学相关的乳腺肿块。

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY
Journal of Mid-life Health Pub Date : 2024-04-01 Epub Date: 2024-07-05 DOI:10.4103/jmh.jmh_187_23
Pratik Bharatbhai Desai, Killol Nathubhai Desai, Nirav Sureshbhai Panchal
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引用次数: 0

摘要

导言:可触及的乳房肿块是临床医生和外科医生常见的诊断问题。细针穿刺细胞学检查(FNAC)具有成本低、样本处理时间短、痛苦小、血肿机会少、不适感轻等诸多优点。采用细胞块制备的 FNAC 进一步提高了灵敏度和特异性,几乎达到 100%。目的:本研究的目的是对可触及的乳腺肿块病例进行相关性分析,包括敏感性、特异性、阳性和阴性预测值(NPV),以及有无细胞块的 FNAC 与最终组织病理学的诊断准确性进行比较:2018年1月至2019年12月,经人类伦理研究委员会批准,开展了一项横断面前瞻性研究,共纳入65名患者。经临床诊断为乳腺肿块的患者在我院接受了带细胞阻滞的 FNAC 诊断,随后进行了组织病理学检查:无细胞阻滞的 FNAC 敏感性、特异性、阳性预测值 (PPV)、NPV、有效率和诊断准确率分别为 91.3%、100%、100%、90.1%、86.2% 和 96.5%。带细胞块的 FNAC 敏感性、特异性、PPV、NPV、有效率和诊断准确率均为 100%。我们的所有结果都优于标准估计值:结论:细针穿刺细胞学检查是一种方便患者、简易、可靠、可重复和简单的诊断检查。只要结合细胞块制备,就能提高 FNAC 诊断的准确性,其准确性可媲美黄金标准活检和组织病理学检查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Utility of the United Kingdom National Health Services Breast Screening Program Diagnostic Protocol in Fine-needle Aspiration Cytology with Cell Block Preparation in Cases of Palpable Breast Lumps: A Reliable, Fast, and Accurate Diagnostic Method for the Assessment of Breast Lumps with Histopathologic Correlation.

Introduction: A palpable breast lump is a common diagnostic problem for clinicians and surgeons. Fine-needle aspiration cytology (FNAC) has many advantages such as less cost, less sample processing time, less pain, less chance of hematoma, and less discomfort. FNAC with cell block preparation further increased both sensitivity and specificity by nearly 100%. With the cell block preparation, we can also use newer tests like estrogen receptor-progesterone receptor-human epidermal growth factor receptor 2.

Aims: The aim of this study was to derive conclusions about the correlation, including sensitivity, specificity, positive and negative predictive values (NPVs), and the diagnostic accuracy of FNAC, with or without cell blocks, compared to the final histopathology in cases of palpable breast masses.

Materials and methods: A cross-sectional prospective study was conducted after getting approval from the Human Ethics Research Committee from January 2018 to December 2019, which included 65 patients. Patients diagnosed clinically for breast lumps who underwent diagnostic FNAC with cell block, followed by a histopathological examination at our hospital, were included in the study.

Results: FNAC without cell block sensitivity, specificity, positive predictive value (PPV), NPV, efficiency rate, and diagnostic accuracy are 91.3%, 100%, 100%, 90.1%, 86.2%, and 96.5%, respectively. FNAC with cell block sensitivity, specificity, PPV, NPV, efficiency rate, and diagnostic accuracy are all 100%. All of our results beat the standard estimate.

Conclusions: Fine-needle aspiration cytology is a patient-friendly, easy, reliable, repeatable, and simple diagnostic test. Whenever it is combined with cell block preparation, improves the accuracy of FNAC diagnosis which is more accurate and comparable to golden-standard biopsy with histopathology examination.

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来源期刊
Journal of Mid-life Health
Journal of Mid-life Health Social Sciences-Health (social science)
CiteScore
1.70
自引率
9.10%
发文量
39
审稿时长
43 weeks
期刊介绍: Journal of mid-life health is the official journal of the Indian Menopause society published Quarterly in January, April, July and October. It is peer reviewed, scientific journal of mid-life health and its problems. It includes all aspects of mid-life health, preventive as well as curative. The journal publishes on subjects such as gynecology, neurology, geriatrics, psychiatry, endocrinology, urology, andrology, psychology, healthy ageing, cardiovascular health, bone health, quality of life etc. as relevant of men and women in their midlife. The Journal provides a visible platform to the researchers as well as clinicians to publish their experiences in this area thereby helping in the promotion of mid-life health leading to healthy ageing, growing need due to increasing life expectancy. The Editorial team has maintained high standards and published original research papers, case reports and review articles from the best of the best contributors both national & international, consistently so that now, it has become a great tool in the hands of menopause practitioners.
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