无菌激活自身免疫中的 RNA 传感途径

IF 5.3 2区生物学 Q2 CELL BIOLOGY

Journal of Molecular Cell Biology Pub Date : 2024-08-14 DOI:10.1093/jmcb/mjae029

Jiaxin Li, Junyan Zhu, Hui Yang, Fajian Hou

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引用次数: 0

摘要

在宿主抵御病原体感染以维持细胞平衡的过程中，RNA 感知通路发挥着关键作用。然而，即使在没有感染的情况下，某些内源性自身 RNA 仍是 RNA 感知通路的激活剂。自身配体对 RNA 传感器的不适当激活会导致全身性炎症和自身免疫性疾病。在这篇综述中，我们总结了目前关于 RNA 感测器无菌激活的研究结果，以及它在自身免疫、炎症性疾病和治疗中的意义。

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Sterile activation of RNA-sensing pathways in autoimmunity.

RNA-sensing pathways play a pivotal role in host defense against pathogenic infections to maintain cellular homeostasis. However, even in the absence of infection, certain endogenous self-RNAs still serve as the activators of RNA-sensing pathways. The inappropriate activation of RNA sensors by self-ligands leads to systemic inflammation and autoimmune diseases. In this review, we summarize current findings on the sterile activation of RNA sensors, as well as its implications in autoimmunity, inflammatory diseases, and therapeutics.

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来源期刊

Journal of Molecular Cell Biology CELL BIOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

1383

期刊介绍： The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.