精神分裂症患者自杀的年龄分层风险。

IF 5.3 2区 医学 Q1 PSYCHIATRY
Yueh-Pin Lin, Wen-Yin Chen, Chun-Hung Pan, Sheng-Shiang Su, Shang-Ying Tsai, Chiao-Chicy Chen, Chian-Jue Kuo
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引用次数: 0

摘要

目的:精神分裂症与自杀风险增加有关。可能由于样本量的限制,很少有研究调查不同年龄段的自杀风险:本研究从台湾的 "国民健康保险研究数据库 "中筛选出 195,787 名精神分裂症患者,时间跨度为 2000 年 1 月 1 日至 2019 年 12 月 31 日。在研究期间,有 3848 名患者死于自杀。我们计算了按年龄分层的自杀标准化死亡率(SMR)。在这项按年龄分层的嵌套病例对照研究中,我们采用了风险集抽样法,按照年龄、性别和首次确诊精神分裂症的年份,将每个病例与 4 个在世的对照组进行匹配。条件逻辑回归用于估算年龄分层风险概况:结论:SMR 在《结论》中最高:自杀的风险因素因年龄而异。这项研究的结果可用于优化医疗干预措施,预防精神分裂症患者自杀。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-stratified risk of suicide in patients with schizophrenia

Objectives

Schizophrenia is associated with an increased risk of suicide. Few studies have investigated the risk of suicide across different ages, likely due to limitations around sample size.

Methods

From the National Health Insurance Research Database in Taiwan, this study identified 195,787 patients with schizophrenia from January 1, 2000, to December 31, 2019. During the study period, 3848 patients died from suicide. We calculated the standardized mortality ratio (SMR) for suicide stratified by age. In this age-stratified, nested case–control study, risk set sampling was used to match each case with 4 living controls by age, sex, and the year of the first diagnosis with schizophrenia. Conditional logistic regression was used for estimating age-stratified risk profiles.

Results

The SMR was the highest in the <25 years age group (52.8) and inversely correlated with age. Unemployment was associated with an increased risk of suicide in the 25 to 34, 35 to 44, 45 to 54, and 55 to 64 years age groups. Depressive and sleep disorders before suicide were more common among suicide cases with schizophrenia than among controls across all age groups. Drug-induced and alcohol-induced mental disorders were significantly associated with suicide but were observed only in the age group younger than 54. Heart disease, pneumonia, and moderate or severe renal disease were risk factors for suicide in the age groups less than 65.

Conclusions

The risk factors for suicide differ by age. This study's findings can be used to optimize health-care interventions for preventing suicide in patients with schizophrenia.

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来源期刊
Acta Psychiatrica Scandinavica
Acta Psychiatrica Scandinavica 医学-精神病学
CiteScore
11.20
自引率
3.00%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.
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