含氮杂环、双环[1.1.1]戊烷和二氟碘烷（III）试剂的光化学串联反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-08-28 DOI:10.1039/d4ob01020e

Yaqing Zhu , Fengchao Yi , Ningning Zhou , Yi Zhang , Ying Zhang , Xia Zhao , Kui Lu

{"title":"含氮杂环、双环[1.1.1]戊烷和二氟碘烷（III）试剂的光化学串联反应。","authors":"Yaqing Zhu , Fengchao Yi , Ningning Zhou , Yi Zhang , Ying Zhang , Xia Zhao , Kui Lu","doi":"10.1039/d4ob01020e","DOIUrl":null,"url":null,"abstract":"<div><p>A visible light-induced difluoroalkylation/heteroarylation of [1.1.1]propellane with nitrogen containing heterocycles and difluoroiodane(<span>iii</span>) reagents was achieved. Various heteroarenes and difluoroiodane(<span>iii</span>) reagents exhibited good compatibility, yielding the desired products in moderate to good yields. The accessibility of the reagents and the mild reaction conditions establish this method as an alternative and practical strategy for accessing diverse 1-difluoroalkyl-3-heteroaryl bicyclo[1.1.1]pentanes (BCPs).</p></div>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":"22 34","pages":"Pages 7024-7034"},"PeriodicalIF":2.7000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Photochemical tandem reaction of nitrogen containing heterocycles, bicyclo[1.1.1]pentane, and difluoroiodane(iii) reagents†\",\"authors\":\"Yaqing Zhu , Fengchao Yi , Ningning Zhou , Yi Zhang , Ying Zhang , Xia Zhao , Kui Lu\",\"doi\":\"10.1039/d4ob01020e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A visible light-induced difluoroalkylation/heteroarylation of [1.1.1]propellane with nitrogen containing heterocycles and difluoroiodane(<span>iii</span>) reagents was achieved. Various heteroarenes and difluoroiodane(<span>iii</span>) reagents exhibited good compatibility, yielding the desired products in moderate to good yields. The accessibility of the reagents and the mild reaction conditions establish this method as an alternative and practical strategy for accessing diverse 1-difluoroalkyl-3-heteroaryl bicyclo[1.1.1]pentanes (BCPs).</p></div>\",\"PeriodicalId\":96,\"journal\":{\"name\":\"Organic & Biomolecular Chemistry\",\"volume\":\"22 34\",\"pages\":\"Pages 7024-7034\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic & Biomolecular Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1477052024006992\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052024006992","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

利用含氮杂环和二氟碘烷（III）试剂实现了可见光诱导的[1.1.1]丙烷二氟烷基化/异芳基化反应。各种杂环和二氟碘烷（III）试剂表现出良好的兼容性，以中等至良好的产率获得所需的产物。试剂的易获得性和温和的反应条件使该方法成为获得多种 1-二氟烷基-3-杂芳基双环[1.1.1]戊烷（BCPs）的一种替代性实用策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Photochemical tandem reaction of nitrogen containing heterocycles, bicyclo[1.1.1]pentane, and difluoroiodane(iii) reagents†

查看原文本刊更多论文

Photochemical tandem reaction of nitrogen containing heterocycles, bicyclo[1.1.1]pentane, and difluoroiodane(iii) reagents†

A visible light-induced difluoroalkylation/heteroarylation of [1.1.1]propellane with nitrogen containing heterocycles and difluoroiodane(iii) reagents was achieved. Various heteroarenes and difluoroiodane(iii) reagents exhibited good compatibility, yielding the desired products in moderate to good yields. The accessibility of the reagents and the mild reaction conditions establish this method as an alternative and practical strategy for accessing diverse 1-difluoroalkyl-3-heteroaryl bicyclo[1.1.1]pentanes (BCPs).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.