解开心灵与肠道的联系:人类微生物群对认知的影响

IF 20.6 1区 医学 Q1 MICROBIOLOGY
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引用次数: 0

摘要

本视角探讨了目前对肠道微生物群对明显健康的人类和代谢性疾病患者认知功能的影响的理解。我们讨论了肠道微生物群的改变如何影响认知过程,不仅关注细菌的组成,还关注肠道微生物群中经常被忽视的成分,如噬菌体和真核生物,以及微生物的功能。我们研究了肠道微生物可能与中枢神经系统沟通的机制,强调了这些相互作用的复杂性。我们全面概述了微生物群-肠道-大脑相互作用这一新兴领域及其对认知健康的意义。此外,我们还总结了旨在促进认知复原力和降低认知障碍风险的新型治疗策略,重点是针对肠道微生物群的干预措施。深入了解微生物组-大脑轴对于开发旨在改善认知健康的创新疗法至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unlocking the mind-gut connection: Impact of human microbiome on cognition

This perspective explores the current understanding of the gut microbiota’s impact on cognitive function in apparently healthy humans and in individuals with metabolic disease. We discuss how alterations in gut microbiota can influence cognitive processes, focusing not only on bacterial composition but also on often overlooked components of the gut microbiota, such as bacteriophages and eukaryotes, as well as microbial functionality. We examine the mechanisms through which gut microbes might communicate with the central nervous system, highlighting the complexity of these interactions. We provide a comprehensive overview of the emerging field of microbiota-gut-brain interactions and its significance for cognitive health. Additionally, we summarize novel therapeutic strategies designed to promote cognitive resilience and reduce the risk of cognitive disorders, focusing on interventions that target the gut microbiota. An in-depth understanding of the microbiome-brain axis is imperative for developing innovative treatments aimed at improving cognitive health.

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来源期刊
Cell host & microbe
Cell host & microbe 生物-微生物学
CiteScore
45.10
自引率
1.70%
发文量
201
审稿时长
4-8 weeks
期刊介绍: Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.
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