种植体周围纤维化的形成和维持需要表达瘦素受体的骨骼细胞

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering Pub Date : 2024-08-14 DOI:10.1038/s41551-024-01244-0

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引用次数: 0

摘要

骨科植入物周围纤维组织的细胞组成及其形成的遗传途径尚不清楚。我们发现，瘦素受体表达细胞会激活粘附G蛋白偶联受体F5（ADGRF5）途径，形成假体周围纤维组织。抑制瘦素受体表达细胞中的ADGRF5可以预防和逆转种植体周围纤维化。

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The formation and maintenance of peri-implant fibrosis requires skeletal cells expressing the leptin receptor

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The formation and maintenance of peri-implant fibrosis requires skeletal cells expressing the leptin receptor

The cellular composition of fibrous tissue around orthopaedic implants and the genetic pathways involved in its formation are unclear. We find that leptin-receptor-expressing cells activate the adhesion G-protein-coupled receptor F5 (ADGRF5) pathway to form peri-implant fibrous tissue. Inhibition of ADGRF5 in leptin-receptor-expressing cells can prevent and reverse peri-implant fibrosis.

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.