心脏再生需要细胞衰老

IF 9.4 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
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引用次数: 0

摘要

我们利用蛋白质组学和单细胞 RNA 测序描述了受伤小鼠心脏的再生衰老特征。我们报告了新生小鼠心脏再生和成年小鼠琼脂糖介导的心脏修复都需要瞬时衰老,并深入探讨了 Egr1 在衰老和再生中的重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cellular senescence is required for cardiac regeneration

Cellular senescence is required for cardiac regeneration
We describe the regenerative senescence signature of the injured mouse heart using proteomics and single-cell RNA sequencing. We report that transient senescence is required for neonatal mouse heart regeneration and for agrin-mediated cardiac repair in adult mice and provide insights into the essential role of Egr1 in senescence and regeneration.
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CiteScore
5.70
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