评估克里米亚-刚果出血热患者的 YKL-40 水平与临床严重程度之间的关系。

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI:10.1080/20477724.2024.2392225
Murat Aydin, Nurten Nur Aydin, Esra Laloğlu
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引用次数: 0

摘要

克里米亚-刚果出血热(CCHF)是一种广泛传播的蜱媒病毒性疾病。YKL-40(又称几丁质酶-3-样-1蛋白)是由各种免疫细胞释放的一种急性期蛋白。本研究旨在探讨YKL-40水平与CCHF临床病程和预后之间的关系。研究纳入了我院 2022 年 4 月 15 日至 8 月 30 日期间收治的 78 名聚合酶链反应检测结果呈阳性的慢性阻塞性肺疾病患者。患者被分为严重和非严重两组。此外,还设立了由 22 名健康人组成的对照组。患者血清中 YKL-40 的平均水平明显高于对照组(分别为 106.8 ng/mL ± 91.2 和 47.1 ng/mL ± 35.3;p p = 0.001)。对 YKL-40 水平进行接收器操作特征分析后发现,区分重度和非重度患者的曲线下面积为 0.925。以 90.7 纳克/毫升为临界值,YKL-40 水平的灵敏度为 97%,特异度为 84%。在CCHF患者入院时测量的YKL-40水平可作为临床病程和预后的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the relationship between YKL-40 level and clinical severity in patients with Crimean-Congo hemorrhagic fever.

Crimean-Congo hemorrhagic fever (CCHF) is a widespread tick-borne viral disease. YKL-40 (also known as chitinase-3-like-1 protein) is an acute phase protein released by various immune cells. The purpose of this study was to investigate the relationship between YKL-40 level and the clinical course and prognosis of CCHF. The study included 78 patients who were admitted to our hospital between April 15 and 30 August 2022 and had a positive polymerase chain reaction test result for CCHF. The patients were divided into two groups, severe and non-severe. In addition, a control group consisting of 22 healthy people was established. Mean serum YKL-40 levels were significantly higher in patients than controls (106.8 ng/mL ± 91.2 and 47.1 ng/mL ± 35.3, respectively; p < 0.001). However, mean YKL-40 levels were also significantly higher in patients with severe CCHF compared to non-severe cases (173.3 ± 112.3 and 67.5 ± 41.7, respectively; p < 0.001). A comparison of the 10 exitus patients and the 68 survivors revealed significantly higher YKL-40 levels in the exitus group (mean: 214.0 ± 139.0 and 92.8 ± 73.6, respectively; p = 0.001). A receiver operating characteristic analysis for YKL-40 levels to distinguish between severe and non-severe patients found an area under the curve of 0.925. YKL-40 levels were measured with a sensitivity of 97% and a specificity of 84% with a cutoff value of 90.7 ng/mL. YKL-40 levels measured at the time of hospital presentation in patients with CCHF can be used as a biomarker for clinical course and prognosis.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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