针对口腔癌和口腔潜在恶性疾病的局部瘤内免疫调节剂给药。

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-08-12 DOI:10.1016/j.oraloncology.2024.106986

Nourhan I. Hussein , Andrea H. Molina , Gemalene M. Sunga , Moran Amit , Yu Leo Lei , Xiao Zhao , Jeffrey D. Hartgerink , Andrew G. Sikora , Simon Young

{"title":"针对口腔癌和口腔潜在恶性疾病的局部瘤内免疫调节剂给药。","authors":"Nourhan I. Hussein , Andrea H. Molina , Gemalene M. Sunga , Moran Amit , Yu Leo Lei , Xiao Zhao , Jeffrey D. Hartgerink , Andrew G. Sikora , Simon Young","doi":"10.1016/j.oraloncology.2024.106986","DOIUrl":null,"url":null,"abstract":"<div><p>Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.</p></div>","PeriodicalId":4,"journal":{"name":"ACS Applied Energy Materials","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Localized intratumoral delivery of immunomodulators for oral cancer and oral potentially malignant disorders\",\"authors\":\"Nourhan I. Hussein , Andrea H. Molina , Gemalene M. Sunga , Moran Amit , Yu Leo Lei , Xiao Zhao , Jeffrey D. Hartgerink , Andrew G. Sikora , Simon Young\",\"doi\":\"10.1016/j.oraloncology.2024.106986\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.</p></div>\",\"PeriodicalId\":4,\"journal\":{\"name\":\"ACS Applied Energy Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Energy Materials\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S136883752400304X\",\"RegionNum\":3,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Energy Materials","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S136883752400304X","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

摘要

免疫疗法已发展成为现代癌症治疗的一种重要方式。遗憾的是，检查点抑制剂免疫疗法目前是全身给药，需要频繁给药，这可能导致毒性和严重的不良反应，有时甚至是致命的不良反应。针对口腔癌和口腔潜在恶性疾病的免疫调节剂局部给药有望实现最大的治疗潜力并减少全身不良反应。本综述将讨论目前标准护理全身疗法的局限性，并重点介绍用于口腔癌和口腔潜在恶性疾病免疫疗法的局部瘤内给药平台的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Localized intratumoral delivery of immunomodulators for oral cancer and oral potentially malignant disorders

Immunotherapy has developed into an important modality of modern cancer treatment. Unfortunately, checkpoint inhibitor immunotherapies are currently delivered systemically and require frequent administration, which can result in toxicity and severe, sometimes fatal, adverse events. Localized delivery of immunomodulators for oral cancer and oral potentially malignant disorders offers the promise of maximum therapeutic potential and reduced systemic adverse effects. This review will discuss the limitations of current standard-of-care systemic therapies and highlight research advances in localized, intratumoral delivery platforms for immunotherapy for oral cancer and oral potentially malignant disorders.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.