单侧早期假性角膜剥脱性青光眼的虹膜周围和黄斑血管密度。

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Journal of Glaucoma Pub Date : 2024-12-01 Epub Date: 2024-08-15 DOI:10.1097/IJG.0000000000002483
Nilgun Solmaz, Turker Oba
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引用次数: 0

摘要

摘要:在早期假性角膜外翻性青光眼中,鼻侧径向毛细血管密度(RPC-VD)降低,而视网膜神经纤维层(RNFL)从鼻侧到颞侧变薄。目的:与健康对照组相比,评估单侧早期假性角膜外翻性青光眼(PXG)和未受影响的同侧眼的毛细血管密度(VD):这项横断面研究包括 28 名 PXG 患者的 28 只眼和 28 名非青光眼、无假性角膜剥脱的同侧眼,以及 28 名健康参与者的 28 只眼。所有受试者都接受了光学相干断层血管成像(OCTA)检查。比较了各组之间的径向毛细血管周围VD(RPC-VD)、黄斑VD、视网膜神经纤维层(RNFL)厚度和神经节细胞复合体(GCC)厚度:结果:与同侧眼和对照组相比,PXG 眼的平均 RPC-VD 和 RNFL 厚度明显降低:在 PXG 的早期阶段,RNFL 参数似乎比 RPC-VD 参数具有更好的诊断能力。处于临床前阶段的同侧眼可能不会表现出任何 RPC-VD 和 RNFL 损失,目前的 OCTA 技术可以检测到这些损失。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Peripapillary and Macular Vessel Density in Unilateral Early Pseudoexfoliation Glaucoma.

Prcis: In early pseudoexfoliation glaucoma (PXG), radial peripapillary capillary vessel density (RPC-VD) was reduced nasally, while the retinal nerve fiber layer (RNFL) thinned from the nasal to temporal sectors. Nonglaucomatous fellow eyes demonstrated no RPC-VD or RNFL loss in comparison to the controls.

Purpose: To evaluate peripapillary and macular vessel density (VD) in unilateral early PXG and unaffected fellow eyes compared with healthy controls.

Methods: This cross-sectional study included 28 eyes with PXG and 28 nonglaucomatous, pseudoexfoliation-free fellow eyes of 28 patients, and 28 eyes of 28 healthy participants. All subjects underwent optical coherence tomography angiography (OCTA) imaging. RPC-VD, macular VD, retinal nerve fiber layer (RNFL) thickness, and ganglion cell complex (GCC) thickness were compared among the groups.

Results: The average RPC-VD and RNFL thickness were significantly reduced in PXG eyes compared with both fellow eyes and the control group ( P <0.001-0.002). In fellow eyes, neither RNFL thickness nor RPC-VD parameters differed from controls. In sector-based analysis, RPC-VD loss in the PXG eyes was significant in the nasal-superior, nasal-inferior, superonasal, and inferonasal sectors ( P =0.005-0.031), while RNFL thinning extended from the nasal sectors toward the superotemporal and temporal-superior sectors ( P <0.001-0.014). RPC-VD was strongly correlated with average and all sector RNFL thicknesses ( r =0.402-0.759, P <0.001-0.034). While perifoveal GCC differed from both fellow and control eyes ( P <0.001), there was no significant difference in macular VD parameters among the groups. RPC-VD and RNFL had comparable area under receiver operating curve (AUROC) values in the average and nasal sectors, while RPC-VD had no ability to distinguish PXG from controls in the superotemporal and inferotemporal sectors.

Conclusion: In the early stages of PXG, RNFL parameters mostly appear to have better diagnostic ability than RPC-VD parameters. Fellow eyes in the preclinical stage may not exhibit any RPC-VD and RNFL loss detectable by current OCTA technology.

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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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