巨噬细胞挖掘癌症中的肥胖悖论

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-08-13 DOI:10.1016/j.immuni.2024.07.013

引用次数: 0

摘要

肥胖相关癌症患者对免疫检查点阻断剂的反应增加，但其机制仍不清楚。在最近一期《自然》杂志上，Bader 等人报告说，小鼠肥胖会诱导巨噬细胞 PD-1 上调，从而促进肿瘤生长，同时增强免疫疗法的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Macrophages dig into the obesity paradox in cancer

Response to immune checkpoint blockade is increased in obesity-related cancers, but the mechanisms remain unclear. In a recent issue of Nature, Bader et al. report that obesity in mice induces macrophage PD-1 upregulation to promote tumor growth while potentiating immunotherapy responses.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.