子宫肌瘤:目前对新型药物靶点和创新治疗策略的研究。

IF 4.6 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Expert Opinion on Therapeutic Targets Pub Date : 2024-08-01 Epub Date: 2024-08-13 DOI:10.1080/14728222.2024.2390094
Michal Ciebiera, Jakub Kociuba, Mohamed Ali, Obianuju Sandra Madueke-Laveaux, Qiwei Yang, Monika Bączkowska, Marta Włodarczyk, Natalia Żeber-Lubecka, Elżbieta Zarychta, Ana Corachán, Samar Alkhrait, Vafaei Somayeh, Iana Malasevskaia, Tomasz Łoziński, Piotr Laudański, Robert Spaczynski, Grzegorz Jakiel, Ayman Al-Hendy
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引用次数: 0

摘要

简介子宫肌瘤是影响女性生殖道的最常见的非恶性肿瘤,是一项重大的医学挑战。本文重点介绍了试图确定子宫肌瘤治疗中新型非激素治疗靶点和策略的最新研究:这篇综述分析了天然物质的药理学和生物学作用机制,以及微生物组在 UFs 中的作用。这项研究旨在确定这些化合物在预防和治疗尿毒症中的潜在作用:专家意见:虽然治疗尿毒症的方法有很多,但现有的药物疗法尚未得到优化。这篇综述强调了维生素 D、EGCG 和其他天然化合物以及微生物组的生物潜力,认为它们是治疗和预防 UF 的有前途的替代品。尽管这些物质在这一领域已经得到了很好的分析,但我们仍建议在这些化合物或益生菌的治疗领域开展进一步的研究,尤其是随机研究。另外,随着数据质量的不断提高,我们建议在征得患者同意的前提下,考虑将其纳入临床实践。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Uterine fibroids: current research on novel drug targets and innovative therapeutic strategies.

Introduction: Uterine fibroids, the most common nonmalignant tumors affecting the female genital tract, are a significant medical challenge. This article focuses on the most recent studies that attempted to identify novel non-hormonal therapeutic targets and strategies in UF therapy.

Areas covered: This review covers the analysis of the pharmacological and biological mechanisms of the action of natural substances and the role of the microbiome in reference to UFs. This study aimed to determine the potential role of these compounds in UF prevention and therapy.

Expert opinion: While there are numerous approaches for treating UFs, available drug therapies for disease control have not been optimized yet. This review highlights the biological potential of vitamin D, EGCG and other natural compounds, as well as the microbiome, as promising alternatives in UF management and prevention. Although these substances have been quite well analyzed in this area, we still recommend conducting further studies, particularly randomized ones, in the field of therapy with these compounds or probiotics. Alternatively, as the quality of data continues to improve, we propose the consideration of their integration into clinical practice, in alignment with the patient's preferences and consent.

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来源期刊
CiteScore
8.90
自引率
1.70%
发文量
58
审稿时长
3 months
期刊介绍: The journal evaluates molecules, signalling pathways, receptors and other therapeutic targets and their potential as candidates for drug development. Articles in this journal focus on the molecular level and early preclinical studies. Articles should not include clinical information including specific drugs and clinical trials. The Editors welcome: Reviews covering novel disease targets at the molecular level and information on early preclinical studies and their implications for future drug development. Articles should not include clinical information including specific drugs and clinical trials. Original research papers reporting results of target selection and validation studies and basic mechanism of action studies for investigative and marketed drugs. The audience consists of scientists, managers and decision makers in the pharmaceutical industry, academic researchers working in the field of molecular medicine and others closely involved in R&D.
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