适配体在衰老和老年相关疾病领域的应用

LiuJun Xu, Beier Jiang, WenJing Qiu, Chunxia Jiang, Feng Zhang, Weihong Tan
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引用次数: 0

摘要

世界正在向老龄化社会过渡,这一现象增加了罹患老年相关疾病的风险,对人类健康构成重大威胁。如何延缓衰老或实现健康老龄化已成为一个紧迫而关键的问题。目前,多种抗衰老药物正在研发中,并已进入临床验证阶段。然而,由于缺乏特异性衰老生物标志物,阻碍了诊断和治疗衰老及老年相关疾病的相应靶点的确定。万向聚合体(Aptamer)是一种新型分子识别工具,在诊断和治疗各种疾病方面有着广泛的应用。此外,基于细胞的选择也有可能识别出可作为疾病生物标志物的未识别分子。近年来,人们对衰老和老年相关疾病的关注度急剧上升,适配体在这一领域的应用也在迅速发展。因此,本综述将简明扼要地概述老龄化问题,并重点介绍如何在老龄化和老年相关疾病中利用适配体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The application of aptamers in the field of aging and age-related diseases

The application of aptamers in the field of aging and age-related diseases

The world is transitioning into an aging society, a phenomenon that escalates the risk of age-related diseases, posing a significant threat to human health. Addressing how to delay aging or achieve healthy aging has become an urgent and pivotal issue. Presently, diverse anti-aging drugs are under development and entering clinical validation stages. However, the absence of specific aging biomarkers has hindered the identification of corresponding targets for diagnosing and treating aging and age-related diseases. Aptamer, a novel molecular recognition tool, has found broad application in diagnosing and treating various diseases. Additionally, cell-based selection holds the potential to identify unidentified molecules that could serve as biomarkers for diseases. Recent years have seen a surge in attention towards aging and age-related diseases, with the application of aptamer in this domain rapidly advancing. Consequently, this review will provide a concise overview of the aging, with a focus on the utilisation of aptamer in aging and age-related diseases.

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