虎耳草中的半萜及其化学分类学意义

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-08 DOI:10.1016/j.bse.2024.104877

Rui Ao, Ming-Hui Li, Zi-Nan Xiao, Xue-Lian Tang, Jun-Sheng Zhang, Hua Zhang

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引用次数: 0

摘要

通过对这些化合物的化学研究，分离出了一种新的卡迪烷倍半萜（）和十二种已知的倍半萜（-）。这些化合物的结构是利用包括核磁共振、质谱在内的一整套综合光谱技术推导出来的，其绝对构型是通过 TDDFT 计算和化学方法相结合确定的。化合物对 MDA-MB-231 细胞株具有温和的细胞毒性，在 50 μmol/L 和 100 μmol/L 浓度下的抑制率分别为 46.8% 和 54.2%。首次报道了 Menispermaceae 家族中存在Ⅳ-化合物。此外，还讨论了分离物的化学分类学意义。

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Sesquiterpenes from Tinospora sinensis and their chemotaxonomic significance

Chemical investigation of the Tinospora sinensis led to the isolation of a new cadinane sesquiterpene (1) and twelve known sesquiterpenes (2−13). The structures of these compounds were deduced using a suite of comprehensive spectroscopic techniques including NMR, MS etc., and the absolute configuration of 1 was established through a combination of TDDFT calculations and chemical methods. Compound 1 demonstrated mild cytotoxicity against MDA-MB-231 cell line, with an inhibition rate of 46.8% and 54.2% at 50 μmol/L and 100 μmol/L, respectively. Compounds 1, 5−13 were reported to exist in the Menispermaceae family for the first time. Furthermore, the chemotaxonomic significance of the isolates is also discussed.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.