生物仿制药在扁平苔藓中的疗效和安全性：全面综述

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-08-12 DOI:10.2147/ccid.s478840

Eman Almukhadeb, Almuntsrbellah Almudimeegh, Khalid Nabil Nagshabandi, Yousef Luay Alsuwailem, Asem Shadid

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引用次数: 0

摘要

摘要：化脓性扁平湿疹（Hidradenitis Suppurativa，HS）又称痤疮（Acne Inversa），是一种慢性、复发性炎症性皮肤病，主要累及腋窝和腹股沟等分泌腺丰富的部位。该病以疼痛性结节、脓肿和瘢痕为特征，对患者的心理影响深远。目前的治疗方法旨在通过非药物和药物相结合的方式来控制症状和预防新的病变。新兴的生物仿制药以较低的成本复制了已知生物制剂的疗效和安全性，为治疗这种使人衰弱的皮肤疾病提供了新的选择。本综述总结了近期的研究，解释了生物仿制药在HS中的作用，强调了其扩大有效治疗选择的潜力。关键词：生物制剂；生物仿制药；化脓性扁平苔癣；综述

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The Efficacy and Safety of Biosimilars in Hidradenitis Suppurativa: A Comprehensive Review

Abstract: Hidradenitis Suppurativa (HS), also known as Acne Inversa, is a chronic, recurrent inflammatory skin condition primarily affecting apocrine gland-bearing areas, such as the axilla and groin. Characterized by painful nodules, abscesses, and scarring, and has a profound psychological impact on patients. Current treatments aim to manage symptoms and prevent new lesions with a combination of non-pharmacological and pharmacological approaches. Emerging biosimilars, which replicate the efficacy and safety profiles of known biologics at a lower cost, offer new options for treating this debilitating cutaneous disorder. The review summarizes recent studies to explain the role of biosimilars in HS, emphasizing their potential to expand effective treatment options.

Keywords: biologics, biosimilars, hidradenitis suppurativa, review

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.