现代欧洲人新石器时代引入的与 IL23R 相关的保护功能可预防慢性炎症性肠病

bioRxiv - Evolutionary Biology Pub Date : 2024-08-07 DOI:10.1101/2024.08.06.606840

Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Archaeological Civilization Disease Consortium (ACDC), Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber

{"title":"现代欧洲人新石器时代引入的与 IL23R 相关的保护功能可预防慢性炎症性肠病","authors":"Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Archaeological Civilization Disease Consortium (ACDC), Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber","doi":"10.1101/2024.08.06.606840","DOIUrl":null,"url":null,"abstract":"Background The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel disease (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe.","PeriodicalId":501183,"journal":{"name":"bioRxiv - Evolutionary Biology","volume":"22 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans\",\"authors\":\"Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Archaeological Civilization Disease Consortium (ACDC), Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber\",\"doi\":\"10.1101/2024.08.06.606840\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel disease (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe.\",\"PeriodicalId\":501183,\"journal\":{\"name\":\"bioRxiv - Evolutionary Biology\",\"volume\":\"22 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"bioRxiv - Evolutionary Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.08.06.606840\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv - Evolutionary Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.06.606840","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景 IL23R 基因中的低位变异 rs11209026-A 在欧洲人中对免疫相关疾病，尤其是炎症性肠病 (IBD) 有显著的保护作用。目前，A 基因等位基因在欧洲的平均出现率为 5%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans

Background The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel disease (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

bioRxiv - Evolutionary Biology

自引率

0.00%

发文量