{"title":"含哌啶磺酰胺的黄酮醇衍生物的抗 TMV 活性：设计、合成和机理研究","authors":"Zhiling Sun, Wei Zeng, Qing Zhou, Yujiao Qiu, Yuzhi Hu, Jieyu Li, Hong Fu, Hongqian Zou, Wei Xue","doi":"10.1016/j.arabjc.2024.105944","DOIUrl":null,"url":null,"abstract":"<div><p>A series of flavonol derivatives containing piperidine sulfonamide were designed and synthesized. The EC<sub>50</sub> values for the curative of tobacco mosaic virus (TMV) by <strong>Z6</strong> and <strong>Z22</strong> were 108.2 and 102.7 <em>μ</em>g/mL, respectively, outperforming the control agent ningenmycin (NNM) with an EC<sub>50</sub> value of 253.8 <em>μ</em>g/mL. Additionally, the EC<sub>50</sub> values for the protective activity of <strong>Z6</strong> and <strong>Z21</strong> were 100.9 and 123.2 <em>μ</em>g/mL, respectively, also surpassing the control agent NNM with an EC<sub>50</sub> value of 203.7 <em>μ</em>g/mL. Microscale thermophoresis (MST) and molecular docking test showed that <strong>Z6</strong> bound well with tobacco mosaic virus coat protein (TMV-CP). The biological safety test showed that <strong>Z6</strong> had almost no effect on seed germination and seedling growth. After treatment with <strong>Z6</strong>, the chlorophyll content and superoxide dismutase (SOD) activity in tobacco leaves increased, while the malondialdehyde (MDA) content decreased. Therefore, <strong>Z6</strong> has a high probability as a potential antiviral agent.</p></div>","PeriodicalId":249,"journal":{"name":"Arabian Journal of Chemistry","volume":"17 9","pages":"Article 105944"},"PeriodicalIF":5.3000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878535224003460/pdfft?md5=96490a38436c0cc92c71f0a49307f5d1&pid=1-s2.0-S1878535224003460-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Anti-TMV activity of flavonol derivatives containing piperidine sulfonamide: Design, synthesis, mechanism study\",\"authors\":\"Zhiling Sun, Wei Zeng, Qing Zhou, Yujiao Qiu, Yuzhi Hu, Jieyu Li, Hong Fu, Hongqian Zou, Wei Xue\",\"doi\":\"10.1016/j.arabjc.2024.105944\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A series of flavonol derivatives containing piperidine sulfonamide were designed and synthesized. The EC<sub>50</sub> values for the curative of tobacco mosaic virus (TMV) by <strong>Z6</strong> and <strong>Z22</strong> were 108.2 and 102.7 <em>μ</em>g/mL, respectively, outperforming the control agent ningenmycin (NNM) with an EC<sub>50</sub> value of 253.8 <em>μ</em>g/mL. Additionally, the EC<sub>50</sub> values for the protective activity of <strong>Z6</strong> and <strong>Z21</strong> were 100.9 and 123.2 <em>μ</em>g/mL, respectively, also surpassing the control agent NNM with an EC<sub>50</sub> value of 203.7 <em>μ</em>g/mL. Microscale thermophoresis (MST) and molecular docking test showed that <strong>Z6</strong> bound well with tobacco mosaic virus coat protein (TMV-CP). The biological safety test showed that <strong>Z6</strong> had almost no effect on seed germination and seedling growth. After treatment with <strong>Z6</strong>, the chlorophyll content and superoxide dismutase (SOD) activity in tobacco leaves increased, while the malondialdehyde (MDA) content decreased. Therefore, <strong>Z6</strong> has a high probability as a potential antiviral agent.</p></div>\",\"PeriodicalId\":249,\"journal\":{\"name\":\"Arabian Journal of Chemistry\",\"volume\":\"17 9\",\"pages\":\"Article 105944\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-07-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1878535224003460/pdfft?md5=96490a38436c0cc92c71f0a49307f5d1&pid=1-s2.0-S1878535224003460-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arabian Journal of Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1878535224003460\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arabian Journal of Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1878535224003460","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Anti-TMV activity of flavonol derivatives containing piperidine sulfonamide: Design, synthesis, mechanism study
A series of flavonol derivatives containing piperidine sulfonamide were designed and synthesized. The EC50 values for the curative of tobacco mosaic virus (TMV) by Z6 and Z22 were 108.2 and 102.7 μg/mL, respectively, outperforming the control agent ningenmycin (NNM) with an EC50 value of 253.8 μg/mL. Additionally, the EC50 values for the protective activity of Z6 and Z21 were 100.9 and 123.2 μg/mL, respectively, also surpassing the control agent NNM with an EC50 value of 203.7 μg/mL. Microscale thermophoresis (MST) and molecular docking test showed that Z6 bound well with tobacco mosaic virus coat protein (TMV-CP). The biological safety test showed that Z6 had almost no effect on seed germination and seedling growth. After treatment with Z6, the chlorophyll content and superoxide dismutase (SOD) activity in tobacco leaves increased, while the malondialdehyde (MDA) content decreased. Therefore, Z6 has a high probability as a potential antiviral agent.
期刊介绍：
The Arabian Journal of Chemistry is an English language, peer-reviewed scholarly publication in the area of chemistry. The Arabian Journal of Chemistry publishes original papers, reviews and short reports on, but not limited to: inorganic, physical, organic, analytical and biochemistry.
The Arabian Journal of Chemistry is issued by the Arab Union of Chemists and is published by King Saud University together with the Saudi Chemical Society in collaboration with Elsevier and is edited by an international group of eminent researchers.
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