利用荧光进行术中可视化、引导和温度监测的增强现实眼镜

bioRxiv Pub Date : 2024-08-09 DOI:10.1101/2024.08.08.607031
Oscar Cipolato, Matthias Fauconneau, Paige J. LeValley, Robert Nißler, Benjamin Suter, Inge K. Herrmann
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引用次数: 0

摘要

荧光引导外科技术,包括肿瘤切除和组织焊接,通过加强控制,最大限度地减少组织损伤,改善恢复和疗效,正在推动外科手术的精确性向前发展。然而,将荧光信号可视化和温度监测无缝集成到手术工作流程中尚未完全实现,仍然是一项挑战,因此限制了其有效性和临床广泛采用。为了解决这个问题,我们推出了一种增强现实(AR)面罩,旨在将纳米材料激发、荧光检测和手术过程中的温度监测结合起来。我们使用先进的荧光纳米粒子,如掺杂吲哚菁绿的粒子和单壁碳纳米管,对增强现实面罩进行了评估。通过将荧光可视化、激发监测和精确温度控制整合到一个 AR 平台中,我们为外科医生提供了一个全面的视角,既能看到手术区域,也能看到肉眼看不到的表层下情况。这种集成通过确保焊接温度保持在治疗阈值内,并通过实时荧光信号精确引导激光,显著提高了荧光引导手术以及包括激光组织焊接在内的新兴技术的安全性和有效性。所展示的技术不仅增强了现有的外科技术,还支持在传统方法不足的领域开发新的策略和传感技术,标志着精准外科的重大进展,最终可改善病人护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Augmented Reality Visor for Intraoperative Visualization, Guidance and Temperature Monitoring using Fluorescence
Fluorescence-guided surgical techniques, including tumor resection and tissue soldering, are advancing the frontiers of surgical precision by offering enhanced control that minimizes tissue damage and improves recovery as well as outcomes. However, integrating the visualization of the fluorescent signal and temperature monitoring seamlessly into surgical workflows has not been fully realized and remains a challenge, thus limiting their effectiveness and wide-spread clinical adoption. To address this issue, we introduce an augmented reality (AR) visor designed to unite nanomaterial excitation along with fluorescence detection, and temperature monitoring during surgical procedures. The AR visor was evaluated using advanced fluorescent nanoparticles, such as indocyanine green-doped particles and singlewalled carbon nanotubes. By consolidating fluorescence visualization, excitation monitoring, and precise temperature control into a single AR platform, we equip surgeons with a comprehensive view of both the surgical field and sub-surface conditions invisible to the naked eye. This integration notably improves the safety and efficacy of fluorescence-guided surgeries, as well as emerging technologies including laser tissue soldering, by ensuring the soldering temperature stays within therapeutic thresholds and the laser is accurately guided by real-time fluorescence signals. The presented technology not only enhances existing surgical techniques but also supports the development of new strategies and sensing technologies in areas where traditional methods fall short, marking significant progress in precision surgery, which could ultimately improve patient care.
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