发育内皮基因座 1:血管内源性因子的现状与未来

Daisong Jiang, Honghua Yue, Weitao Liang, Zhong Wu
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引用次数: 0

摘要

发育内皮基因座-1(DEL-1)又称类表皮生长因子重复序列和类盘蛋白 I-结构域-3(EDIL3),它在免疫调节和血管生物学中的多方面作用日益得到认可。DEL-1 是一种主要由内皮细胞产生的蛋白质。它与各种整合素相互作用,调节免疫细胞的行为,如防止不必要的招募和炎症。DEL-1 还能通过促进凋亡细胞的清除过程--排出细胞来帮助消除炎症。由于 DEL-1 在血管完整性和病理学方面的广泛影响,它作为免疫介导的血液疾病、心血管疾病和癌症转移的治疗靶点的潜力已受到关注。然而,关于 DEL-1 的确切功能和机制仍有许多未解之谜。本综述全面研究了 DEL-1 在不同血管环境中的活性,并探讨了其潜在的临床应用。它强调了进一步研究的必要性,以解决现有争议并确定 DEL-1 调节的治疗可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Developmental endothelial locus 1: the present and future of an endogenous factor in vessels
Developmental Endothelial Locus-1 (DEL-1), also known as EGF-like repeat and discoidin I-like domain-3 (EDIL3), is increasingly recognized for its multifaceted roles in immunoregulation and vascular biology. DEL-1 is a protein that is mainly produced by endothelial cells. It interacts with various integrins to regulate the behavior of immune cells, such as preventing unnecessary recruitment and inflammation. DEL-1 also helps in resolving inflammation by promoting efferocytosis, which is the process of clearing apoptotic cells. Its potential as a therapeutic target in immune-mediated blood disorders, cardiovascular diseases, and cancer metastasis has been spotlighted due to its wide-ranging implications in vascular integrity and pathology. However, there are still unanswered questions about DEL-1’s precise functions and mechanisms. This review provides a comprehensive examination of DEL-1’s activity across different vascular contexts and explores its potential clinical applications. It underscores the need for further research to resolve existing controversies and establish the therapeutic viability of DEL-1 modulation.
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