西孟加拉邦一家三级甲等医院采用 GeneXpert MTB/RIF 检测法检测耐药结核病的负担及其临床流行病学方面的问题。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2024-08-14 DOI:10.1016/j.ijmmb.2024.100703

Nupur Pal , Raja Ray , Somenath Kundu , Avijit Hazra , Singdha Sau , Suhita Sur , Shreya Saha , Wasim Mallick

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引用次数: 0

摘要

耐多药结核病（MDRTB）是对人类的严重威胁。印度是耐多药结核病例最多的国家，但由于诊断基础设施不足，大多数病例仍未得到诊断，导致社区传播和死亡率上升。这项为期一年的观察性回顾研究强调了国家消除结核病计划（NTEP）通过 GeneXpert MTB/RIF 检测法及时发现耐药结核病的有效性，并揭示了与之相关的临床流行病学因素。MTB 和 RRTB 的总体检出率分别为 20.70% 和 20.86%。儿科人群的利福平耐药率为 7.69%，艾滋病毒与结核病和 RRTB 的发生密切相关（P＜0.05）。

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Burden of drug-resistant tuberculosis by the GeneXpert MTB/RIF assay and its clinico-epidemiological aspects at a tertiary care hospital in West Bengal

Multidrug -resistant tuberculosis (MDRTB) is a serious threat to mankind. India has the highest number of MDRTB cases, although majority remain undiagnosed due to inadequate diagnostic infrastructure, leading to increased community transmission and mortality. This one-year observational retrospective study highlighted the effectiveness of the National Tuberculosis Elimination Program (NTEP) for prompt detection of drug-resistant TB by GeneXpert MTB/RIF assay and revealed its associated clinico-epidemiological factors. The overall detection rates of MTB and RRTB were 20.70 % and 20.86 % respectively. The pediatric population had 7.69 % rifampicin resistance, and HIV was strongly associated with the development of TB and RRTB (P < 0.01).

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.