降低极早产儿毛细血管渗漏综合征死亡率：试点调查

IF 1 4区医学 Q3 PEDIATRICS

Clinical Pediatrics Pub Date : 2024-08-09 DOI:10.1177/00099228241272037

Timothy J Boly, Michell M Lozano-Chinga, Melanie E Reyes-Hernandez, Timothy G Elgin, Zuhair Ballas, Jennifer R Bermick

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引用次数: 0

摘要

新生儿毛细血管渗漏综合征（CLS）是一种罕见的新生儿败血症或炎症损伤后危及生命的疾病。本研究旨在描述一种可改善死亡率和新生儿预后的 CLS 标准化治疗方法。该研究对 10 名妊娠 22 至 26 周出生的婴儿进行了回顾性队列研究，这些婴儿在受到严重炎症损伤后出现 CLS。研究记录并描述了两个时期的诊断时间和治疗方法。在第 2 个阶段，随着临床对 CLS 认识的提高和标准化治疗方法的实施，治疗时间明显缩短，死亡率明显下降。新生儿CLS的早期针对性治疗方法可降低这种高发病率疾病的死亡率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reducing Capillary Leak Syndrome Mortality in Extremely Premature Infants: A Pilot Investigation.

Neonatal capillary leak syndrome (CLS) is a rare, but life-threatening condition following neonatal sepsis or inflammatory injury. The objective of this study was to describe a standardized treatment approach for CLS that improves mortality and neonatal outcomes. A retrospective cohort study of 10 infants born at 22 to 26 weeks of gestation who developed CLS following a significant inflammatory insult was performed. Time to diagnosis and treatment approaches over 2 epochs were recorded and described. In epoch 2, with increased clinical awareness of CLS and implementation of a standardized treatment approach, there was a non-statistically significant decrease in the time to treatment with a significant decrease in mortality. An early targeted treatment approach for neonatal CLS can decrease mortality rates in this highly morbid condition.

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来源期刊

Clinical Pediatrics 医学-小儿科

CiteScore

2.10

自引率

6.20%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Clinical Pediatrics (CLP) a peer-reviewed monthly journal, is a must read for the busy pediatrician. CLP contains state-of-the-art, accurate, concise and down-to earth information on practical, everyday child care topics whether they are clinical, scientific, behavioral, educational, or ethical.