利妥昔单抗治疗滤泡性淋巴瘤后出现外周T细胞快速反应。

IF 3 3区医学 Q2 HEMATOLOGY

Annals of Hematology Pub Date : 2024-12-01 Epub Date: 2024-08-10 DOI:10.1007/s00277-024-05931-5

Cristina Frusteri, Isacco Ferrarini

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引用次数: 0

摘要

滤泡性淋巴瘤患者在接受利妥昔单抗治疗后，经常会出现骨髓反应性T细胞浸润。在一些研究中，骨髓 T 细胞扩增与有效的抗肿瘤反应和良好的预后有关。在这篇手稿中，我们报告了在利妥昔单抗治疗滤泡性淋巴瘤后出现的特别剧烈的 CD4+ T 细胞反应，除了骨髓外，还涉及外周血。外周血 T 细胞反应主要由效应记忆 CD4+ T 细胞组成，可能反映了有效抗肿瘤免疫的扩展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A brisk peripheral T-cell reaction following rituximab treatment for follicular lymphoma.

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A brisk peripheral T-cell reaction following rituximab treatment for follicular lymphoma.

Bone marrow reactive T-cell infiltrates have been frequently observed in patients affected by follicular lymphoma after rituximab treatment. In some studies, bone-marrow T-cell expansion has been associated with an effective anti-tumor response and favorable prognosis. In this manuscript, we report on a particularly brisk CD4⁺ T-cell reaction occurring after rituximab treatment for follicular lymphoma and involving the peripheral blood in addition to the bone marrow. Peripheral blood T-cell reaction was mainly composed of effector-memory CD4⁺ T cells and may reflect the expansion of an effective anti-tumor immunity.

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来源期刊

Annals of Hematology 医学-血液学

CiteScore

5.60

自引率

2.90%

发文量

304

审稿时长

2 months

期刊介绍： Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.