酒精对小鼠时钟同步性和组织昼夜节律平衡的影响

IF 4.5 2区 农林科学 Q1 FOOD SCIENCE & TECHNOLOGY
Luca S. Santovito, Maliha Shaikh, Deepak Sharma, Christopher B. Forsyth, Robin M. Voigt, Ali Keshavarzian, Faraz Bishehsari
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引用次数: 0

摘要

酒精使用障碍是全世界卫生系统日益关注的问题。酒精会对包括肠道和肝脏在内的多个器官造成损害,这些器官主要参与酒精的吸收和代谢。然而,即使个人的饮酒量相当,与酒精相关的器官损伤风险也存在很大差异。可能调节饮酒造成器官损伤风险的因素可能是造成个体间对酒精相关器官损伤易感性差异的原因。越来越多的证据表明,昼夜节律紊乱会加剧酒精相关器官损伤。在此,我们研究了酒精、昼夜节律和小鼠基线、光/暗周期(LCD)规律和转变后的关键组织细胞过程之间的相互作用。我们分析了核心时钟基因(CoClGs)的中枢/外周时钟表达。我们还研究了与酒精损害有关的组织细胞过程的昼夜稳态。这些实验表明,酒精会影响核心时钟基因(CoClGs)的表达,导致中枢-外周不同步,并通过 LCD 的变化而放大。观察到的昼夜节律不同步与酒精相关损害所涉及的关键过程的昼夜节律紊乱有关,尤其是当酒精与 LCD 结合时。这些结果让人们了解到酒精与昼夜节律紊乱相互作用促进器官损伤的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of Alcohol on Clock Synchrony and Tissue Circadian Homeostasis in Mice

Effect of Alcohol on Clock Synchrony and Tissue Circadian Homeostasis in Mice

Alcohol use disorder accounts for a growing worldwide health system concern. Alcohol causes damages to various organs, including intestine and liver, primarily involved in its absorption and metabolism. However, alcohol-related organ damage risk varies significantly among individuals, even when they report consuming comparable dosages of alcohol. Factor(s) that may modulate the risk of organ injuries from alcohol consumption could be responsible for inter-individual variations in susceptibility to alcohol-related organ damages. Accumulating evidence suggests disruptions in circadian rhythm can exacerbate alcohol-related organ damages. Here we investigated the interplay between alcohol, circadian rhythm, and key tissue cellular processes at baseline, after a regular and a shift in the light/dark cycle (LCD) in mice. Central/peripheral clock expression of core clock genes (CoClGs) was analyzed. We also studied circadian homeostasis of tissue cellular processes that are involved in damages from alcohol. These experiments reveal that alcohol affects the expression of CoClGs causing a central-peripheral dyssynchrony, amplified by shift in LCD. The observed circadian clock dyssynchrony was linked to circadian disorganization of key processes involved in the alcohol-related damages, particularly when alcohol was combined with LCD. These results offer insights into the mechanisms by which alcohol interacts with circadian rhythm disruption to promote organ injury.

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来源期刊
Molecular Nutrition & Food Research
Molecular Nutrition & Food Research 工程技术-食品科技
CiteScore
8.70
自引率
1.90%
发文量
250
审稿时长
1.7 months
期刊介绍: Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.
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