踏上生命的蓝图：研究细胞外囊泡在胚胎发育中的关键作用。

IF 2 Q2 OBSTETRICS & GYNECOLOGY

Obstetrics and Gynecology Science Pub Date : 2024-08-09 DOI:10.5468/ogs.24084

Seok Hee Lee

引用次数: 0

摘要

细胞外囊泡（EVs）含有生物分子，如蛋白质、脂类和多种核酸，可改变受体细胞的各种生理和病理过程。本综述从EVs的生物学特性、对胚胎发育的影响以及治疗生殖系统疾病的潜在治疗价值等方面探讨了目前对EVs的认识。从受精到着床前阶段，以及在胚胎发育、细胞分化和器官形成过程中，EVs 在早期胚胎发育中发挥着至关重要的作用。在胚胎着床前，EVs 与母体生殖组织相互作用，促进着床接受能力；在胚胎着床过程中，EVs 调节细胞分化，促进组织形成和维持。EVs 中的异常生物活性分子与发育障碍有关，因此 EVs 可作为生物标记物。此外，EVs 还是潜在的治疗剂，可将遗传物质输送到目标组织或器官。本综述的研究结果强调了 EVs 在胚胎发育过程中细胞间信号传递的潜在作用。这将有助于推进辅助生殖技术和疗法，克服不孕症和发育障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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WITHDRAWN: Embarking on life's blueprint: investigating the crucial involvement of extracellular vesicles in embryo development.

Ahead of print article withdrawn at the author's request due to administrative errors in the journal's processing of the submission.

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来源期刊

Obstetrics and Gynecology Science Medicine-Obstetrics and Gynecology

CiteScore

3.80

自引率

15.80%

发文量

审稿时长

16 weeks

期刊介绍： Obstetrics & Gynecology Science (NLM title: Obstet Gynecol Sci) is an international peer-review journal that published basic, translational, clinical research, and clinical practice guideline to promote women’s health and prevent obstetric and gynecologic disorders. The journal has an international editorial board and is published in English on the 15th day of every other month. Submitted manuscripts should not contain previously published material and should not be under consideration for publication elsewhere. The journal has been publishing articles since 1958. The aim of the journal is to publish original articles, reviews, case reports, short communications, letters to the editor, and video articles that have the potential to change the practices in women''s health care. The journal’s main focus is the diagnosis, treatment, prediction, and prevention of obstetric and gynecologic disorders. Because the life expectancy of Korean and Asian women is increasing, the journal''s editors are particularly interested in the health of elderly women in these population groups. The journal also publishes articles about reproductive biology, stem cell research, and artificial intelligence research for women; additionally, it provides insights into the physiology and mechanisms of obstetric and gynecologic diseases.