斯洛伐克首次发现亚洲样 CPV-2b 的证据:病例报告,一只接种过疫苗的狗出现了急性致命性细小病毒感染病程。

IF 1.8 3区 农林科学 Q2 VETERINARY SCIENCES
Veterinary Research Communications Pub Date : 2024-10-01 Epub Date: 2024-08-09 DOI:10.1007/s11259-024-10492-z
Andrea Pelegrinová, Patrícia Petroušková, Ľuboš Korytár, Anna Ondrejková, Monika Drážovská, Boris Vojtek, Jana Mojžišová, Marián Prokeš, Maroš Kostičák, Ľubica Zákutná, Michal Dolník, René Mandelík
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引用次数: 0

摘要

本研究全面描述了一只接种过疫苗的腊肠犬幼犬感染致命性副病毒的临床过程,并通过对 VP2 基因进行分子氨基酸分析,首次在斯洛伐克发现了一种新的 CPV-2 变体。该犬表现出冷漠、呕吐和血性腹泻等临床症状。在通过商用快速检测确认 CPV-2 感染后,开始了强化治疗。该犬在入院 48 小时内死亡。采集了直肠拭子样本,使用 PCR 方法检测了 CPV-2,并进行了测序。在患者体内检测到的病毒与源自亚洲的 CPV-2c 株系有关,与欧洲的 CPV-2b 株系无关。病毒序列具有典型的亚洲毒株基因特征(VP2:5Gly、267Tyr、324Ile、370Arg 和 440Thr)。系统发育分析将该菌株归类为与亚洲 CPV-2c 株系相似的菌株。据信,它来自于获得 426Asp 突变的与 CPV-2c 相似的亚洲毒株。我们的这一发现首次证明了斯洛伐克境内存在类似亚洲的 CPV-2b 株系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The first evidence of Asian-like CPV-2b in Slovakia in a vaccinated dog with an acute fatal course of parvovirus infection: a case report.

The first evidence of Asian-like CPV-2b in Slovakia in a vaccinated dog with an acute fatal course of parvovirus infection: a case report.

This study provides a comprehensive description of the clinical course of a fatal parvovirus infection in a vaccinated dachshund puppy, along with the first identification of a new CPV-2 variant in Slovakia, elucidated through molecular amino acid analysis of the VP2 gene. The dog exhibited clinical signs such as apathy, vomiting, and bloody diarrhea. After confirming CPV-2 infection with a commercial snap test, intensive therapy was initiated. The dog succumbed within 48 h of admission. A rectal swab sample was collected, CPV-2 was examined using the PCR method, and sequenced. The virus detected in the patient was related to strains of CPV-2c of Asian origin and unrelated to European CPV-2b strains. The sequence had genetic signatures typical of Asian strains (VP2: 5Gly, 267Tyr, 324Ile, 370Arg, and 440Thr). Phylogenetic analysis classified this strain as similar to Asian strains of CPV-2c. It is believed to be derived from an Asian strain similar to CPV-2c that acquired the 426Asp mutation. With this finding, we present the first evidence of an Asian-like CPV-2b strain in the territory of Slovakia.

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来源期刊
Veterinary Research Communications
Veterinary Research Communications 农林科学-兽医学
CiteScore
2.50
自引率
0.00%
发文量
173
审稿时长
3 months
期刊介绍: Veterinary Research Communications publishes fully refereed research articles and topical reviews on all aspects of the veterinary sciences. Interdisciplinary articles are particularly encouraged, as are well argued reviews, even if they are somewhat controversial. The journal is an appropriate medium in which to publish new methods, newly described diseases and new pathological findings, as these are applied to animals. The material should be of international rather than local interest. As it deliberately seeks a wide coverage, Veterinary Research Communications provides its readers with a means of keeping abreast of current developments in the entire field of veterinary science.
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