Amare Aregay, Jan Slunečko, Miša Korva, Petra Bogovic, Katarina Resman Rus, Nataša Knap, Jana Beicht, Mareike Kubinski, Giulietta Saletti, Tatjana Avšič-Županc, Imke Steffen, Franc Strle, Albert D M E Osterhaus, Guus F Rimmelzwaan
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引用次数: 0
摘要
蜱传脑炎病毒(TBEV)疫苗突破(VBT)感染在流行地区并不少见。有关其临床和免疫学结果的研究很少。我们评估了之前接种过疫苗的受试者在 TBE 后病毒特异性抗体和 T 细胞反应的强度和特异性,并将其结果与未接种过疫苗的 TBE 患者和接种过疫苗但未感染 VBT 的受试者的结果进行了比较。未接种疫苗的研究对象感染 TBEV 后会出现 E 蛋白和非结构蛋白 1 (NS1) 的病毒特异性抗体反应,以及结构蛋白和其他非结构蛋白 (NS) 的 T 细胞反应。VBT感染后,NS1特异性抗体反应明显减弱,而病毒特异性T细胞对NS蛋白的反应则相对较强。在住院期间,VBT 感染主要导致中度到重度疾病。未接种疫苗的康复患者体内的TBEV EDIII和NS1特异性抗体水平与TBE的严重程度和感染后早期的神经症状成反比。
Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins.
Tick-borne encephalitis virus (TBEV) vaccine breakthrough (VBT) infections are not uncommon in endemic areas. The clinical and immunological outcomes have been poorly investigated. We assessed the magnitude and specificity of virus-specific antibody and T cell responses after TBE in previously vaccinated subjects and compared the results with those of unvaccinated TBE patients and study subjects that received vaccination without VBT infection. Symptomatic TBEV infection of unvaccinated study subjects induced virus-specific antibody responses to the E protein and non-structural protein 1 (NS1) as well as T cell responses to structural and other non-structural (NS) proteins. After VBT infections, significantly impaired NS1-specific antibody responses were observed, while the virus-specific T cell responses to the NS proteins were relatively strong. VBT infection caused predominantly moderate to severe disease during hospitalization. The level of TBEV EDIII- and NS1-specific antibodies in unvaccinated convalescent patients inversely correlated with TBE severity and neurological symptoms early after infection.
NPJ VaccinesImmunology and Microbiology-Immunology
CiteScore
11.90
自引率
4.30%
发文量
146
审稿时长
11 weeks
期刊介绍:
Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.