Arturo Bonometti, Alexander Tzankov, Ilaria Alborelli, Norman F Russkamp, Susanne Dertinger, Stefan Dirnhofer
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引用次数: 0
摘要
窦内骨髓受累是一种不常见的组织学模式，在少数 B 细胞和 T 细胞淋巴瘤中可以观察到。套细胞淋巴瘤是一种在生物学和预后上异质性的B细胞淋巴瘤，常累及骨髓，呈间质性、结节状-鳞状或弥漫型。窦内骨髓受累在这种淋巴瘤中仅见于传闻。在此，我们描述了四例被诊断为晚期套细胞淋巴瘤患者的临床、组织病理学和分子特征，这些病例显示了窦内骨髓受累以及其他特殊的免疫表型特征。由于类似病例可能代表了骨髓诊断组织病理学的一个相关问题，我们还回顾了相关文献，讨论了鼻腔内骨髓受累的B细胞和T细胞淋巴瘤的鉴别诊断。
Intrasinusoidal bone marrow involvement in mantle cell lymphoma: a case series with review of the main differential diagnoses.
Intrasinusoidal bone marrow involvement is an infrequent histological pattern observed in a limited number of B and T cell lymphomas. Mantle cell lymphoma is a biologically and prognostically heterogeneous B cell lymphoma that frequently involves the bone marrow, with interstitial, nodular-paratrabecular, or diffuse patterns. Intrasinusoidal bone marrow involvement has been described only anecdotally in this lymphoma. Here, we describe the clinical, histopathological, and molecular features of four patients diagnosed with advanced-stage mantle cell lymphoma, showing intrasinusoidal bone marrow involvement, and other peculiar immunophenotypical features. As similar cases may represent a relevant issue in bone marrow diagnostic histopathology, we also reviewed the literature to discuss differential diagnoses of B and T cell lymphomas with intrasinusoidal bone marrow involvement.
期刊介绍：
Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.
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