Jaishree S, Kousalya Selvaraj, Prakash S, Vineesh D
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引用次数: 0
摘要
乳腺癌（BC）是导致女性健康不良的主要原因之一，也是继肺癌之后最具破坏性的疾病。癌症 "一词是指细胞异常增殖导致的一系列问题，尤其是会扩散到身体其他部位的细胞。对于 BC 相关的癌症，目前接受的治疗方法是手术，然后进行化疗或放疗。然而，由于化疗和放疗会对健康组织和器官产生不良影响，因此很少能有效治疗 BC。因此，在靶向给药系统（DDS）中使用 NPs 已成为治疗 BC 的一种有前途的策略。本综述概述了纳米粒子介导的 DDS 的最新临床研究，这些研究提供了一种常用于治疗乳腺癌的新型治疗策略。
Innovative Nanoscale Drug Delivery Strategies for Breast Carcinoma: A Comprehensive Exploration.
Breast cancer (BC) is one of the major causes of poor health in women and the most devastating disease after lung cancer. The term "cancer" refers to a collection of problems resulting from abnormal cell proliferation, particularly cells that can spread to other parts of the body. Surgery, followed by chemotherapy or radiotherapy, is now accepted for BC-related cancers. However, chemotherapy and radiotherapy are rarely effective in the treatment of BC due to the adverse effects of these treatments on healthy tissues and organs. Consequently, the use of NPs in targeted Drug Delivery Systems (DDSs) has emerged as a promising strategy for BC treatment. This review provides a summary of recent clinical investigations of nanoparticle-mediated DDS that offer a novel therapeutic strategy commonly used for the treatment of breast cancer.
期刊介绍：
Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.
More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.
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