{"title":"探索 Asl-us-Soos（Glycyrrhiza glabra L.）治疗呼吸系统疾病的潜力--民族药学和药理学综述。","authors":"Fuzela Sherwani, Mohammad Nawab","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Asl-us-Soos (Glycyrrhiza glabra L.) has been used as a therapeutic agent in the treatment of respiratory, digestive, and neurological disorders since ancient times in Unani Medicine. Its therapeutic uses have been documented in Unani pharmacopeia, classical textbooks, and manuscripts based on experience in clinical practices. Asl-us-Soos (AS) and its compound preparations are recommended in the treatment of respiratory diseases such as Dhat al-Janb (pleurisy), Dhat al-Ri'a (pneumonia), Jamod us Sadr (pulmonary apoplexy), Diq al-Nafas (asthma), Sil (thiasis), and Diq (pulmonary tuberculosis).</p><p><strong>Objectives: </strong>This review aimed to provide insight into ethno-medicinal uses, pharmacological activities, and phytochemical profile of AS. The review also highlights the prospects in the development of potential drug molecules for various respiratory ailments.</p><p><strong>Methods: </strong>This review is based on a search of authentic Unani classical literature and major databases such as Science Direct, Medline (via PubMed), Google Scholar, Scopus, and Web of Science. The studies published between January 2001 and February 2022 were included in this study.</p><p><strong>Results: </strong>This review found that AS had medicinal uses in various respiratory disorders. Its roots are used as single drug and compound formulations for the treatment of dry cough, bronchial asthma, bronchitis, and pneumonia. In addition, AS contains active phytoconstituents such as glycyrrhizin (glycyrrhizic acid), isoliquiritigenin, glabridin, and licochalcone A. They have been extensively studied using in vitro and in vivo models and were found to exhibit pharmacological effects in pulmonary tuberculosis, pulmonary carcinoma, emphysema, bronchial asthma, pneumonia, and upper respiratory tract infections. Moreover, glycyrrhizin has been found to possess therapeutic potential against COVID-19.</p><p><strong>Conclusion: </strong>This review concludes that AS is a potent anti-tumor, anti-inflammatory, anti-microbial, anti-oxidant, expectorant, and antitussive drug. This plant could be an important source for the development of new drug compounds for various respiratory diseases.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploring the Potential of Asl-us-Soos (Glycyrrhiza glabra L.) in the Treatment of Respiratory Diseases-An Ethnomedicinal and Pharmacological Review.\",\"authors\":\"Fuzela Sherwani, Mohammad Nawab\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Asl-us-Soos (Glycyrrhiza glabra L.) has been used as a therapeutic agent in the treatment of respiratory, digestive, and neurological disorders since ancient times in Unani Medicine. Its therapeutic uses have been documented in Unani pharmacopeia, classical textbooks, and manuscripts based on experience in clinical practices. Asl-us-Soos (AS) and its compound preparations are recommended in the treatment of respiratory diseases such as Dhat al-Janb (pleurisy), Dhat al-Ri'a (pneumonia), Jamod us Sadr (pulmonary apoplexy), Diq al-Nafas (asthma), Sil (thiasis), and Diq (pulmonary tuberculosis).</p><p><strong>Objectives: </strong>This review aimed to provide insight into ethno-medicinal uses, pharmacological activities, and phytochemical profile of AS. The review also highlights the prospects in the development of potential drug molecules for various respiratory ailments.</p><p><strong>Methods: </strong>This review is based on a search of authentic Unani classical literature and major databases such as Science Direct, Medline (via PubMed), Google Scholar, Scopus, and Web of Science. The studies published between January 2001 and February 2022 were included in this study.</p><p><strong>Results: </strong>This review found that AS had medicinal uses in various respiratory disorders. Its roots are used as single drug and compound formulations for the treatment of dry cough, bronchial asthma, bronchitis, and pneumonia. In addition, AS contains active phytoconstituents such as glycyrrhizin (glycyrrhizic acid), isoliquiritigenin, glabridin, and licochalcone A. They have been extensively studied using in vitro and in vivo models and were found to exhibit pharmacological effects in pulmonary tuberculosis, pulmonary carcinoma, emphysema, bronchial asthma, pneumonia, and upper respiratory tract infections. Moreover, glycyrrhizin has been found to possess therapeutic potential against COVID-19.</p><p><strong>Conclusion: </strong>This review concludes that AS is a potent anti-tumor, anti-inflammatory, anti-microbial, anti-oxidant, expectorant, and antitussive drug. 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引用次数: 0
摘要
背景：自古以来，Asl-us-Soos（Glycyrrhiza glabra L.）在尤那尼医学中一直被用作治疗呼吸系统、消化系统和神经系统疾病的药物。乌纳尼药典、经典教科书和基于临床实践经验的手稿中都记载了它的治疗用途。Asl-us-Soos （AS）及其复方制剂被推荐用于治疗呼吸系统疾病，如 Dhat al-Janb（胸膜炎）、Dhat al-Ri'a（肺炎）、Jamod us Sadr（肺水肿）、Diq al-Nafas（哮喘）、Sil（牛皮癣）和 Diq（肺结核）：本综述旨在深入探讨 AS 的民族药用、药理活性和植物化学成分。综述还强调了针对各种呼吸系统疾病开发潜在药物分子的前景：本综述基于对真实的尤那尼经典文献和主要数据库（如 Science Direct、Medline（通过 PubMed）、Google Scholar、Scopus 和 Web of Science）的检索。本研究纳入了 2001 年 1 月至 2022 年 2 月间发表的研究：综述发现，强直性脊柱炎可用于治疗各种呼吸系统疾病。其根茎可作为单药或复方制剂用于治疗干咳、支气管哮喘、支气管炎和肺炎。此外，AS 还含有活性植物成分，如甘草苷（甘草酸）、isisiquiritigenin、glabridin 和 licochalcone A，已利用体外和体内模型对其进行了广泛研究，发现它们对肺结核、肺癌、肺气肿、支气管哮喘、肺炎和上呼吸道感染具有药理作用。此外，还发现甘草酸苷对 COVID-19 具有治疗潜力：本综述认为，AS 是一种有效的抗肿瘤、抗炎、抗微生物、抗氧化、祛痰和止咳药物。这种植物可能是开发治疗各种呼吸道疾病的新化合物的重要来源。
Exploring the Potential of Asl-us-Soos (Glycyrrhiza glabra L.) in the Treatment of Respiratory Diseases-An Ethnomedicinal and Pharmacological Review.
Background: Asl-us-Soos (Glycyrrhiza glabra L.) has been used as a therapeutic agent in the treatment of respiratory, digestive, and neurological disorders since ancient times in Unani Medicine. Its therapeutic uses have been documented in Unani pharmacopeia, classical textbooks, and manuscripts based on experience in clinical practices. Asl-us-Soos (AS) and its compound preparations are recommended in the treatment of respiratory diseases such as Dhat al-Janb (pleurisy), Dhat al-Ri'a (pneumonia), Jamod us Sadr (pulmonary apoplexy), Diq al-Nafas (asthma), Sil (thiasis), and Diq (pulmonary tuberculosis).
Objectives: This review aimed to provide insight into ethno-medicinal uses, pharmacological activities, and phytochemical profile of AS. The review also highlights the prospects in the development of potential drug molecules for various respiratory ailments.
Methods: This review is based on a search of authentic Unani classical literature and major databases such as Science Direct, Medline (via PubMed), Google Scholar, Scopus, and Web of Science. The studies published between January 2001 and February 2022 were included in this study.
Results: This review found that AS had medicinal uses in various respiratory disorders. Its roots are used as single drug and compound formulations for the treatment of dry cough, bronchial asthma, bronchitis, and pneumonia. In addition, AS contains active phytoconstituents such as glycyrrhizin (glycyrrhizic acid), isoliquiritigenin, glabridin, and licochalcone A. They have been extensively studied using in vitro and in vivo models and were found to exhibit pharmacological effects in pulmonary tuberculosis, pulmonary carcinoma, emphysema, bronchial asthma, pneumonia, and upper respiratory tract infections. Moreover, glycyrrhizin has been found to possess therapeutic potential against COVID-19.
Conclusion: This review concludes that AS is a potent anti-tumor, anti-inflammatory, anti-microbial, anti-oxidant, expectorant, and antitussive drug. This plant could be an important source for the development of new drug compounds for various respiratory diseases.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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