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引用次数: 0
摘要
玻璃化技术在辅助生殖技术（ART）中有着重要的应用，该技术已被广泛用于卵母细胞和胚胎的冷冻保存。然而，由于表观遗传学易受冷冻程序引起的环境变化的影响，人们对卵母细胞和胚胎玻璃化的潜在表观遗传学后果表示担忧。本综述全面总结了冷冻保存--尤其是 ART 中的玻璃化方法--对卵母细胞和胚胎的影响。多项研究报告了基因组状态不同方面的变化，这些变化直接影响受精胚胎的质量。 本综述旨在评估有关卵母细胞玻璃化导致玻璃化卵母细胞和早期胚胎发生表观遗传学修饰的现有文献，包括与 ART 相关的 DNA 修饰、RNA 甲基化、组蛋白修饰和 microRNA。
Epigenetics modification among vitrified oocytes and early embryos derived from them: a narrative review.
Vitrification has important application in assisted reproductive technology (ART) and this technique has been widely used in the cryopreservation of oocytes and embryos. However, due to susceptibility of epigenetic modifications to environmental changes induced by cryopreservation procedures, there are concerns about the potential epigenetic consequences of oocyte and embryo vitrification. This review comprehensively summarized the effect of cryopreservation-especially the vitrification method in ART-on oocytes and embryos. Various studies have reported changes in different aspects of genomic status which directly affect the quality of fertilized embryos. The objective of this review is to assess existing literature on the epigenetic modifications that occur in vitrified oocytes and early embryos resulting from oocyte vitrification, including DNA modifications, RNA methylation, histone modification and microRNAs related to ART.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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