阴离子对三维结构域互换的细胞色素 c 二聚体的结构和稳定性的影响

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-08-02 DOI:10.1093/chemle/upae150

Kodai Fujiwara, Michiko Ryuzaki, Masaru Yamanaka, Tsuyoshi Mashima, Tomonori Saotome, Shun-ichi Kidokoro, Shun Hirota

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引用次数: 0

摘要

蛋白质的结构和稳定性受到离子的影响。我们以前曾报道过细胞色素 c 可以形成三维结构域互换二聚体。细胞色素 c 结构域互换二聚体的结构在各向同性阴离子的存在下变得更加紧凑，而二聚体的热稳定性则随着基于霍夫迈斯特系列的各向混沌阴离子的加入而降低。将细胞色素 c 在柠檬酸根离子存在下于 50 °C孵育可形成二聚体。

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Anion effects on the structure and stability of 3D domain-swapped cytochrome c dimer

The structure and stability of proteins are affected by ions. We have previously reported that cytochrome c can form a 3D domain-swapped dimer. The structure of the cytochrome c domain-swapped dimer becomes more compact in the presence of kosmotropic anions, whereas the thermal stability of the dimer decreased with addition of chaotropic anions based on the Hofmeister series. Dimers were formed by incubating cytochrome c at 50 °C in the presence of citrate ions.

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来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry