从 mRNA-LNP 疫苗生产的角度评述封闭式喷射反应器 (CIJR)

IF 4.9 3区 工程技术 Q1 ENGINEERING, CHEMICAL
Le Zhao, Zhiyun Xu, Hua Li, Lu Liu, Songying Chen, Zhengbiao Peng, Guichao Wang
{"title":"从 mRNA-LNP 疫苗生产的角度评述封闭式喷射反应器 (CIJR)","authors":"Le Zhao, Zhiyun Xu, Hua Li, Lu Liu, Songying Chen, Zhengbiao Peng, Guichao Wang","doi":"10.1515/revce-2024-0016","DOIUrl":null,"url":null,"abstract":"In the spotlight of successful breakthrough of the COVID-19 mRNA vaccines, lipid nanoparticles are becoming an important vehicle to deliver a variety of therapeutics. The encapsulation of mRNA using lipids is a self-organizing process that necessitates fast mixing to achieve uniform supersaturation. This is achieved in a confined impinging jet reactor (CIJR) where two input jets collide and fast mix in the mixing chamber. While CIJR is not a new mixing technology, it stands out for its capability to achieve mixing times below a millisecond. This study presents a critical review of major studies concerning CIJRs, starting with the CIJRs’ structures and flow characterization, through experimental and numerical studies, and closing with successful applications in a wide range of chemical/pharmaceutical processes. The detailed mixing principles, scaling-up, and mechanisms of making nanoparticles are discussed focusing mainly on the hydrodynamic aspect. The objective of the review is to supply essential information for the optimized design and operation of CIJRs, catering to both industry and academia.","PeriodicalId":54485,"journal":{"name":"Reviews in Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A review of confined impinging jet reactor (CIJR) with a perspective of mRNA-LNP vaccine production\",\"authors\":\"Le Zhao, Zhiyun Xu, Hua Li, Lu Liu, Songying Chen, Zhengbiao Peng, Guichao Wang\",\"doi\":\"10.1515/revce-2024-0016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the spotlight of successful breakthrough of the COVID-19 mRNA vaccines, lipid nanoparticles are becoming an important vehicle to deliver a variety of therapeutics. The encapsulation of mRNA using lipids is a self-organizing process that necessitates fast mixing to achieve uniform supersaturation. This is achieved in a confined impinging jet reactor (CIJR) where two input jets collide and fast mix in the mixing chamber. While CIJR is not a new mixing technology, it stands out for its capability to achieve mixing times below a millisecond. This study presents a critical review of major studies concerning CIJRs, starting with the CIJRs’ structures and flow characterization, through experimental and numerical studies, and closing with successful applications in a wide range of chemical/pharmaceutical processes. The detailed mixing principles, scaling-up, and mechanisms of making nanoparticles are discussed focusing mainly on the hydrodynamic aspect. The objective of the review is to supply essential information for the optimized design and operation of CIJRs, catering to both industry and academia.\",\"PeriodicalId\":54485,\"journal\":{\"name\":\"Reviews in Chemical Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2024-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reviews in Chemical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1515/revce-2024-0016\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reviews in Chemical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1515/revce-2024-0016","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, CHEMICAL","Score":null,"Total":0}
引用次数: 0

摘要

随着 COVID-19 mRNA 疫苗的成功突破,脂质纳米粒子正成为递送各种治疗药物的重要载体。利用脂质封装 mRNA 是一个自组织过程,需要快速混合以达到均匀的过饱和度。这可以在封闭式撞击射流反应器(CIJR)中实现,在该反应器中,两个输入射流在混合室中碰撞并快速混合。虽然 CIJR 并不是一种新的混合技术,但它能够实现低于毫秒的混合时间,因而脱颖而出。本研究对有关 CIJR 的主要研究进行了批判性回顾,从 CIJR 的结构和流动特征开始,到实验和数值研究,最后到在各种化学/制药过程中的成功应用。书中讨论了详细的混合原理、放大和纳米粒子的制造机制,主要侧重于流体力学方面。本综述旨在为 CIJR 的优化设计和运行提供基本信息,以满足工业界和学术界的需求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A review of confined impinging jet reactor (CIJR) with a perspective of mRNA-LNP vaccine production
In the spotlight of successful breakthrough of the COVID-19 mRNA vaccines, lipid nanoparticles are becoming an important vehicle to deliver a variety of therapeutics. The encapsulation of mRNA using lipids is a self-organizing process that necessitates fast mixing to achieve uniform supersaturation. This is achieved in a confined impinging jet reactor (CIJR) where two input jets collide and fast mix in the mixing chamber. While CIJR is not a new mixing technology, it stands out for its capability to achieve mixing times below a millisecond. This study presents a critical review of major studies concerning CIJRs, starting with the CIJRs’ structures and flow characterization, through experimental and numerical studies, and closing with successful applications in a wide range of chemical/pharmaceutical processes. The detailed mixing principles, scaling-up, and mechanisms of making nanoparticles are discussed focusing mainly on the hydrodynamic aspect. The objective of the review is to supply essential information for the optimized design and operation of CIJRs, catering to both industry and academia.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Reviews in Chemical Engineering
Reviews in Chemical Engineering 工程技术-工程:化工
CiteScore
12.30
自引率
0.00%
发文量
37
审稿时长
6 months
期刊介绍: Reviews in Chemical Engineering publishes authoritative review articles on all aspects of the broad field of chemical engineering and applied chemistry. Its aim is to develop new insights and understanding and to promote interest and research activity in chemical engineering, as well as the application of new developments in these areas. The bimonthly journal publishes peer-reviewed articles by leading chemical engineers, applied scientists and mathematicians. The broad interest today in solutions through chemistry to some of the world’s most challenging problems ensures that Reviews in Chemical Engineering will play a significant role in the growth of the field as a whole.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信