肝内胆管癌中的 Hippo/YAP 靶向：癌症治疗中的前景分子

IF 3 2区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Carcinogenesis Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI:10.1002/mc.23791

Xing Ma, Yangyang Zhou, Ruping Li, Xianmin Ding, Deyu Li, Tingting Pan, Fuqiang Zhang, Wenliang Li

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引用次数: 0

摘要

肝内胆管癌（ICC）的肿瘤发生已被证实与失调的希波/耶斯相关蛋白（YAP）信号通路（Hippo/YAP）密切相关。Hippo/YAP作为主调节因子参与了大量的生理和致癌过程。因此，Hippo/YAP的异常可能成为ICC患者分子治疗途径的致命弱点。在此，我们将全面回顾近期有关 ICC 中 Hippo/YAP 紊乱的潜在机制、如何利用该通路中的关键基因进行诊断以及如何利用该靶通路的机会等方面的研究。

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Targeting Hippo/YAP in intrahepatic cholangiocarcinoma: Promising molecules in cancer therapy.

The tumorigenesis of intrahepatic cholangiocarcinoma (ICC) has been identified to be exceptionally involved in dysregulated Hippo/Yes-associated protein (YAP) signaling pathway (Hippo/YAP). Hippo/YAP functions as a master regulator engaged in a plethora of physiological and oncogenic processes as well. Therefore, the aberrant Hippo/YAP could serve as an Achilles' heel regarding the molecular therapeutic avenues for ICC patients. Herein, we comprehensively review the recent studies about the underlying mechanism of disrupted Hippo/YAP in ICC, how diagnostic values could be utilized upon the critical genes in this pathway, and what opportunities could be given upon this target pathway.

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来源期刊

Molecular Carcinogenesis 医学-生化与分子生物学

CiteScore

7.30

自引率

2.20%

发文量

112

审稿时长

2 months

期刊介绍： Molecular Carcinogenesis publishes articles describing discoveries in basic and clinical science of the mechanisms involved in chemical-, environmental-, physical (e.g., radiation, trauma)-, infection and inflammation-associated cancer development, basic mechanisms of cancer prevention and therapy, the function of oncogenes and tumors suppressors, and the role of biomarkers for cancer risk prediction, molecular diagnosis and prognosis.