与存在牛淋巴细胞抗原-DRB3易感等位基因相比，感染属于 A 组或 B-1 组的牛白血病病毒更容易导致幼牛发生牛白血病。

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2024-08-01 DOI:10.1007/s00705-024-06102-7

Yuki Fujii, Masaki Maezawa, Masataka Akagami, Junko Kawakami, Yuri Fujimoto, Hisashi Inokuma

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引用次数: 0

摘要

在这项研究中，我们比较了不同的牛白血病病毒（BLV）毒株和牛淋巴细胞抗原（BoLA）-DRB3等位基因对患有牛白血病（EBL）的老龄牛的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Infection with bovine leukemia virus belonging to group A or B-1 contributes more strongly to the development of enzootic bovine leukosis in young cattle than the presence of bovine lymphocyte antigen-DRB3 susceptibility alleles

In this study, we compared the effects of different bovine leukemia virus (BLV) strains and bovine lymphocyte antigen (BoLA)-DRB3 alleles in cattle with enzootic bovine leukosis (EBL) aged either <3 years or ≥3 years. The frequency of infection with BLV belonging to group A or B-1 in cattle aged <3 years with EBL was significantly higher than that in cattle aged ≥3 years, regardless of which BoLA-DRB3 allele was present. This suggests that infection with group A or B-1 BLV contributes more strongly to the development of EBL in young cattle than the presence of early-EBL-onset susceptibility BoLA-DRB3 alleles.

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.