评估抗菌肽对细菌性阴道病的活性

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-30 DOI:10.1515/biol-2022-0927

Xuning Kang, Ting Zhao, Yuzhu Song, Jinyang Zhang, Tao Yuan, Qinqin Han

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引用次数: 0

摘要

治疗细菌性阴道病（BV）的新药尚未开发出来，因为人们担心这些药物可能会导致细菌性阴道病的抗生素耐药性增加。抗菌肽（AMPs）是下一代抗生素中最有前景的选择之一。在这项研究中，我们研究了 AMPs Pexiganan、plectasin、melittin 和 cathelicidin-DM 在体外和小鼠 BV 感染模型中对革兰氏阴性菌和革兰氏阳性菌的抑菌活性。结果表明，Pexiganan、melittin 和 cathelicidin-DM 对革兰氏阴性菌和革兰氏阳性菌都有显著的抗菌活性。AMPs 在治疗阴道炎方面具有巨大的临床应用潜力，这项研究为将其用于 BV 的主动免疫预防提供了实验依据。

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Evaluation of the activity of antimicrobial peptides against bacterial vaginosis

New drugs for the treatment of bacterial vaginosis (BV) are yet to be developed due to concerns that they may contribute to the increase in antibiotic resistance in BV. Antimicrobial peptides (AMPs) are one of the most promising options for next-generation antibiotics. In this study, we investigated the bacteriostatic activity of the AMPs Pexiganan, plectasin, melittin, and cathelicidin-DM against Gram-negative and Gram-positive bacteria both in vitro and in a mouse model of BV infection. The results showed that Pexiganan, melittin, and cathelicidin-DM had significant antibacterial activity against both Gram-negative and Gram-positive bacteria. AMPs have great potential for clinical application in the treatment of vaginitis, and this study provides an experimental basis for their use in the active immunoprophylaxis of BV.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.