运动与认知功能 慢性肾脏病:疗效与危害的系统回顾与元分析》。

IF 8.5 1区 医学 Q1 UROLOGY & NEPHROLOGY
Ellen Bradshaw, Abdulfattah Alejmi, Gabriella Rossetti, Giovanni D'Avossa, Jamie Hugo Macdonald
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引用次数: 0

摘要

背景:慢性肾脏病(CKD)患者出现认知障碍的风险较高。运动可以改善认知功能。本研究对随机对照试验(RCTs)进行了系统回顾和荟萃分析,以确定运动在改善 CKD 患者认知功能方面的疗效和危害:系统性文献综述确定了针对任何阶段慢性肾功能衰竭患者的随机对照试验,这些试验采取了锻炼大肌肉群的干预措施,并对认知功能进行了有效的结果测量。首先分析了危害。然后完成了随机效应荟萃分析,并随后进行了有计划的亚组分析,以调查慢性肾脏病分期和治疗方法之间、不同运动类型、持续时间和强度之间以及不同结果方法之间的异质性。最后,对证据质量进行了评级:19项试验随机抽取了1160名参与者。干预组和对照组分别有94次和83次报告了运动伤害。主要分析发现,运动对 CKD 患者的认知能力有微小但具有统计学意义的影响(效应大小 (ES) = 0.22;95% 置信区间 (CI95) = 0.00, 0.44;P = 0.05)。然而,证据质量被评为低。亚组分析发现,运动类型可调节对认知的影响(χ2 = 7.62; P = 0.02),只有有氧运动才会产生积极影响(ES = 0.57; CI95 = 0.21, 0.93; P = 0.002):结论:在所有慢性肾脏病患者中,运动对认知功能的影响虽小,但具有积极的临床意义,而且似乎并无害处。有氧运动尤其有益。然而,由于证据质量不高,必须谨慎解释结果。尽管如此,护理团队仍可选择推荐有氧运动干预来预防认知功能衰退。研究人员应设计无偏见的研究,以明确需要多大强度和多长的运动时间才能最大限度地提高此类运动干预的效率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exercise and Cognitive Function in Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Efficacy and Harms.
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来源期刊
CiteScore
12.20
自引率
3.10%
发文量
514
审稿时长
3-6 weeks
期刊介绍: The Clinical Journal of the American Society of Nephrology strives to establish itself as the foremost authority in communicating and influencing advances in clinical nephrology by (1) swiftly and effectively disseminating pivotal developments in clinical and translational research in nephrology, encompassing innovations in research methods and care delivery; (2) providing context for these advances in relation to future research directions and patient care; and (3) becoming a key voice on issues with potential implications for the clinical practice of nephrology, particularly within the United States. Original manuscript topics cover a range of areas, including Acid/Base and Electrolyte Disorders, Acute Kidney Injury and ICU Nephrology, Chronic Kidney Disease, Clinical Nephrology, Cystic Kidney Disease, Diabetes and the Kidney, Genetics, Geriatric and Palliative Nephrology, Glomerular and Tubulointerstitial Diseases, Hypertension, Maintenance Dialysis, Mineral Metabolism, Nephrolithiasis, and Transplantation.
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