溃疡性结肠炎伴免疫性血小板减少症的生物疗法。

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY

Clinical Journal of Gastroenterology Pub Date : 2024-10-01 Epub Date: 2024-07-31 DOI:10.1007/s12328-024-02022-w

Manabu Nagayama, Yohei Funayama, Osamu Taniguchi, Kaoru Hatano, Kunihiko Oguro, Jun Owada, Hirotsugu Sakamoto, Tomonori Yano, Randy Scott Longman, Hironori Yamamoto

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引用次数: 0

摘要

溃疡性结肠炎（UC）是炎症性肠病的一种亚型，偶尔会出现肠外表现。我们为您介绍一位患有难治性 UC 和免疫性血小板减少症（ITP）的 51 岁男性患者。采用生物制剂（乌斯特库单抗或阿达木单抗）治疗后，结肠炎临床缓解，血小板计数也有所改善。该病例强调了生物制剂在治疗伴有ITP的难治性UC方面的疗效，强调了生物制剂在控制肠道炎症和解决并发血小板减少症方面的潜力，从而有可能避免手术干预。

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Biologic therapy for ulcerative colitis associated with immune thrombocytopenia.

Ulcerative colitis (UC), a subtype of inflammatory bowel disease, occasionally manifests with extraintestinal manifestations. We present a 51-year-old male with refractory UC and immune thrombocytopenia (ITP) resistant to conventional treatments. The introduction of biologics, ustekinumab or adalimumab, resulted in clinical remission of colitis and improvements in platelet count. This case underscores the efficacy of biologics in managing refractory UC associated with ITP, emphasizing their potential to control intestinal inflammation and address concurrent thrombocytopenia, potentially avoiding surgical intervention.

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来源期刊

Clinical Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

182

期刊介绍： The journal publishes Case Reports and Clinical Reviews on all aspects of the digestive tract, liver, biliary tract, and pancreas. Critical Case Reports that show originality or have educational implications for diagnosis and treatment are especially encouraged for submission. Personal reviews of clinical gastroenterology are also welcomed. The journal aims for quick publication of such critical Case Reports and Clinical Reviews.