生化复发前列腺癌患者血液中 PSA 水平与 18F-PSMA-1007 和 18F-choline PET/CT 中标准摄取值最大值 (SUVmax) 和总代谢肿瘤体积 (TMTV) 的相关性。

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Nuclear Medicine Communications Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI:10.1097/MNM.0000000000001881
Vasiliki Fragkiadaki, Emmanouil Panagiotidis, Evaggelia Vlontzou, Theodoros Kalathas, Anna Paschali, Charalampos Kypraios, Vasiliki Chatzipavlidou, Ioannis Datseris
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引用次数: 0

摘要

研究目的在这项前瞻性研究中,我们探讨了根治性治疗后生化复发的前列腺癌患者血液中前列腺特异性抗原(PSA)水平与 18F 前列腺特异性膜抗原(PSMA)-1007 和 18F 胆碱 PET/计算机断层扫描(CT)成像显示的转移灶标准摄取值最大值(SUVmax)和总代谢肿瘤体积(TMTV)的半定量参数之间的相关性:我们对104例经初治明确治疗后生化复发的前列腺癌患者进行了前瞻性检查。所有患者均在 10 天内按随机顺序接受了一次 18F-PSMA-1007 和一次 18F-choline PET/CT 检查,并接受了至少 6 个月(182 ± 10 天)的随访。计算 PET/CT 成像中每个肿瘤病灶的 SUVmax 和代谢肿瘤体积(MTV)的半定量参数,并将每个 MTV 值相加计算 TMTV:结果:根据 Spearman 相关性分析,PSA 水平与 18F-PSMA-1007 PET/CT 转移灶的 SUVmax 和 TMTV 评分之间存在正相关(r = 0.24 和 0.35;P 结论:PSA 水平与 TMTV 评分之间存在正相关:在生化复发患者中,血液中的 PSA 水平与 18F-PSMA-1007 和 18F-Choline PET/CT 成像中转移灶的半定量参数 SUVmax 和 TMTV 之间存在正相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation of PSA blood levels with standard uptake value maximum (SUV max ) and total metabolic tumor volume (TMTV) in 18F-PSMA-1007 and 18F-choline PET/CT in patients with biochemically recurrent prostate cancer.

Objectives: In this prospective study, we investigated the correlation between prostate-specific antigen (PSA) levels in the blood of patients with prostate cancer in biochemical recurrence after radical treatment with the semiquantitative parameters standard uptake value maximum (SUV max ) and the total metabolic tumor volume (TMTV) in the metastatic foci depicted in 18F-prostate-specific membrane antigen (PSMA)-1007 and 18F-choline PET/computed tomography (CT) imaging.

Methods: We prospectively examined 104 patients with biochemical relapse of prostate cancer after primary definitive treatment. All patients underwent one 18F-PSMA-1007 and one 18F-choline PET/CT examination in randomized order within a time frame of 10 days and were followed for at least 6 months (182 ± 10 days). The semiquantitative parameters of SUV max and metabolic tumor volume (MTV) of each neoplastic lesion in PET/CT imaging were calculated, and further summation of each MTV value was done to calculate the TMTV.

Results: According to the Spearman correlation analysis, a positive correlation was found between PSA levels and SUV max and TMTV scores in the metastatic foci of 18F-PSMA-1007 PET/CT ( r  = 0.24 and 0.35, respectively; P  < 0.05) and SUV max in the lesions of 18F-choline PET/CT ( r  = 0.28; P  < 0.0239). However, a positive but NS correlation was demonstrated between values of PSA and TMTV for each lesion in the 18F-choline PET/CT study ( r  = 0.22; P  = 0.0795). The detection rate of the different PSA levels with a cutoff of 1 ng/ml was higher for 18F-PSMA-1007 than 18F-choline.

Conclusion: In biochemical relapse patients there is a positive correlation between PSA levels in the blood and the semiquantitative parameters SUV max and TMTV of the metastatic foci in the 18F-PSMA-1007 and 18F-Choline PET/CT imaging.

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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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