细胞因子与 MicroRNA 之间的相互作用可调节代谢紊乱。

IF 1.9 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Interferon and Cytokine Research Pub Date : 2024-08-01 Epub Date: 2024-07-31 DOI:10.1089/jir.2024.0059

Li Zhang, Li Zhang, Huan Chen, Xiangyong Xu

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引用次数: 0

摘要

代谢紊乱是全球面临的重大公共卫生挑战。新的证据表明，细胞因子和微 RNA（miRNA）通过调节各种代谢过程，包括胰岛素敏感性、脂代谢和炎症，在代谢紊乱的发病机制中发挥着至关重要的作用。本综述全面概述了细胞因子和 miRNA 在肥胖、2 型糖尿病和心血管疾病等代谢性疾病中错综复杂的相互作用。我们讨论了细胞因子-miRNA 网络失调如何导致代谢紊乱的发生和发展，并探讨了针对这些相互作用进行疾病管理的治疗潜力。

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The Interplay Between Cytokines and MicroRNAs to Regulate Metabolic Disorders.

Metabolic disorders represent significant public health challenges worldwide. Emerging evidence suggests that cytokines and microRNAs (miRNAs) play crucial roles in the pathogenesis of metabolic disorders by regulating various metabolic processes, including insulin sensitivity, lipid metabolism, and inflammation. This review provides a comprehensive overview of the intricate interplay between cytokines and miRNAs in the context of metabolic disorders, including obesity, type 2 diabetes, and cardiovascular diseases. We discuss how dysregulation of cytokine-miRNA networks contributes to the development and progression of metabolic disorders and explore the therapeutic potential of targeting these interactions for disease management.

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来源期刊

Journal of Interferon and Cytokine Research 医学-免疫学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

2.2 months

期刊介绍： Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.