成骨细胞分化过程中的 RUNX2 调控：lncRNA 和 miRNA 介导的网络的可能治疗功能

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2024-11-01 DOI:10.1016/j.diff.2024.100803

Pakkath Narayanan Arya, Iyyappan Saranya, Nagarajan Selvamurugan

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引用次数: 0

摘要

成骨分化是骨骼形成和骨重塑的重要过程。它依赖于一个复杂的信号通路和转录因子系统，包括runt相关转录因子2 （RUNX2）。非编码rna （ncRNAs）通过转录后机制控制骨特异性转录因子RUNX2，调控成骨分化。目前研究最多的是microRNAs （miRNAs）和long ncRNAs (lncRNAs)，研究它们在正常和病理情况下如何调控RUNX2促进成骨。本文简要概述了在骨形成过程中lncRNA/miRNA/轴在控制RUNX2表达中的关键作用方面的最新进展。mirna和lncrna作为治疗涉及骨骼和骨骼本身的疾病的治疗剂的可能应用也被涵盖。

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RUNX2 regulation in osteoblast differentiation: A possible therapeutic function of the lncRNA and miRNA-mediated network

Osteogenic differentiation is a crucial process in the formation of the skeleton and the remodeling of bones. It relies on a complex system of signaling pathways and transcription factors, including Runt-related transcription factor 2 (RUNX2). Non-coding RNAs (ncRNAs) control the bone-specific transcription factor RUNX2 through post-transcriptional mechanisms to regulate osteogenic differentiation. The most research has focused on microRNAs (miRNAs) and long ncRNAs (lncRNAs) in studying how they regulate RUNX2 for osteogenesis in both normal and pathological situations. This article provides a concise overview of the recent advancements in understanding the critical roles of lncRNA/miRNA/axes in controlling the expression of RUNX2 during bone formation. The possible application of miRNAs and lncRNAs as therapeutic agents for the treatment of disorders involving the bones and bones itself is also covered.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.