{"title":"金丝桃的一种活性植物化学物质--苏合香酮及其治疗用途","authors":"Kanika Patel, Vandana Gupta, Dinesh Kumar Patel","doi":"10.1016/j.prmcm.2024.100486","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p><em>Saururus chinensis</em> (Saururaceae) is an important medicinal plant used in traditional Chinese and Korean medicine to treat human diseases. Sauchinone, a lignin from <em>Saururus chinensis</em>, is reported to have numerous pharmacological applications in medicine, including anti-oxidant, anti-inflammatory, anti-apoptotic, anti-obesity, and hepatoprotective effects.</p></div><div><h3>Methods</h3><p>The purpose of this review article is to describe the scientific information about sauchinone, its medical importance and pharmacological activity in order to explore the potential health benefits of sauchinone in medicine. In this review, all the scientific information about sauchinone was collected from PubMed, Scopus, Science Direct, Google, and Google Scholar. Additionally, this review also described the pharmacokinetics of sauchinone in order to understand the plasma drug profile of sauchinone with their molecular docking studies.</p></div><div><h3>Results</h3><p>Scientific evidence in this review article described the biological importance of sauchinone in medicine against breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, liver cancer, lung adenocarcinoma, pancreatic ductal adenocarcinoma, osteosarcoma, diabetes, ulcerative colitis, inflammatory bowel disease, osteoarthritis, liver disorders and other human complications. Additionally, molecular docking studies, and pharmacokinetics parameters of sauchinone were also presented in this review to know their therapeutic value in medicine. However, molecular mechanisms of sauchinone were also described in the present review in order to know their biological significance in different kinds of human complications.</p></div><div><h3>Discussion</h3><p>The scientific evidence in this article demonstrates the medicinal importance and the molecular mechanisms involved in the pharmacological activities of sauchinone in medicine. However, detailed preclinical and clinical data are still needed in scientific research to declare the therapeutic efficacy of sauchinone against human diseases.</p></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"12 ","pages":"Article 100486"},"PeriodicalIF":0.0000,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667142524001283/pdfft?md5=b5422e625da004388ea78a66f5f3d5bb&pid=1-s2.0-S2667142524001283-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Sauchinone, an active phytochemical of Saururus Chinensis, and its use as therapeutic\",\"authors\":\"Kanika Patel, Vandana Gupta, Dinesh Kumar Patel\",\"doi\":\"10.1016/j.prmcm.2024.100486\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p><em>Saururus chinensis</em> (Saururaceae) is an important medicinal plant used in traditional Chinese and Korean medicine to treat human diseases. Sauchinone, a lignin from <em>Saururus chinensis</em>, is reported to have numerous pharmacological applications in medicine, including anti-oxidant, anti-inflammatory, anti-apoptotic, anti-obesity, and hepatoprotective effects.</p></div><div><h3>Methods</h3><p>The purpose of this review article is to describe the scientific information about sauchinone, its medical importance and pharmacological activity in order to explore the potential health benefits of sauchinone in medicine. In this review, all the scientific information about sauchinone was collected from PubMed, Scopus, Science Direct, Google, and Google Scholar. Additionally, this review also described the pharmacokinetics of sauchinone in order to understand the plasma drug profile of sauchinone with their molecular docking studies.</p></div><div><h3>Results</h3><p>Scientific evidence in this review article described the biological importance of sauchinone in medicine against breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, liver cancer, lung adenocarcinoma, pancreatic ductal adenocarcinoma, osteosarcoma, diabetes, ulcerative colitis, inflammatory bowel disease, osteoarthritis, liver disorders and other human complications. Additionally, molecular docking studies, and pharmacokinetics parameters of sauchinone were also presented in this review to know their therapeutic value in medicine. However, molecular mechanisms of sauchinone were also described in the present review in order to know their biological significance in different kinds of human complications.</p></div><div><h3>Discussion</h3><p>The scientific evidence in this article demonstrates the medicinal importance and the molecular mechanisms involved in the pharmacological activities of sauchinone in medicine. However, detailed preclinical and clinical data are still needed in scientific research to declare the therapeutic efficacy of sauchinone against human diseases.</p></div>\",\"PeriodicalId\":101013,\"journal\":{\"name\":\"Pharmacological Research - Modern Chinese Medicine\",\"volume\":\"12 \",\"pages\":\"Article 100486\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2667142524001283/pdfft?md5=b5422e625da004388ea78a66f5f3d5bb&pid=1-s2.0-S2667142524001283-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Modern Chinese Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667142524001283\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Modern Chinese Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667142524001283","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
引言 金龙鱼（金龙鱼科）是一种重要的药用植物，在中国和韩国传统医学中被用来治疗人类疾病。本综述文章的目的是描述有关酱醌的科学信息、其在医学上的重要性和药理活性，以探讨酱醌在医学上的潜在保健作用。本综述从 PubMed、Scopus、Science Direct、Google 和 Google Scholar 中收集了所有有关水黄酮的科学信息。此外，本综述还描述了水黄皮酮的药代动力学，以便通过分子对接研究了解水黄皮酮的血浆药物谱。结果这篇综述文章中的科学证据描述了水黄酮在防治乳腺癌、结直肠癌、胃癌、肝细胞癌、肝癌、肺腺癌、胰腺导管腺癌、骨肉瘤、糖尿病、溃疡性结肠炎、炎症性肠病、骨关节炎、肝脏疾病和其他人体并发症方面的重要生物学作用。此外，本综述还介绍了水黄酮的分子对接研究和药代动力学参数，以了解其在医学上的治疗价值。讨论本文中的科学证据证明了苏合香酮在医药方面的重要性以及其药理活性所涉及的分子机制。然而，要宣布酱醌对人类疾病的疗效，还需要详细的临床前和临床科学研究数据。
Sauchinone, an active phytochemical of Saururus Chinensis, and its use as therapeutic
Introduction
Saururus chinensis (Saururaceae) is an important medicinal plant used in traditional Chinese and Korean medicine to treat human diseases. Sauchinone, a lignin from Saururus chinensis, is reported to have numerous pharmacological applications in medicine, including anti-oxidant, anti-inflammatory, anti-apoptotic, anti-obesity, and hepatoprotective effects.
Methods
The purpose of this review article is to describe the scientific information about sauchinone, its medical importance and pharmacological activity in order to explore the potential health benefits of sauchinone in medicine. In this review, all the scientific information about sauchinone was collected from PubMed, Scopus, Science Direct, Google, and Google Scholar. Additionally, this review also described the pharmacokinetics of sauchinone in order to understand the plasma drug profile of sauchinone with their molecular docking studies.
Results
Scientific evidence in this review article described the biological importance of sauchinone in medicine against breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, liver cancer, lung adenocarcinoma, pancreatic ductal adenocarcinoma, osteosarcoma, diabetes, ulcerative colitis, inflammatory bowel disease, osteoarthritis, liver disorders and other human complications. Additionally, molecular docking studies, and pharmacokinetics parameters of sauchinone were also presented in this review to know their therapeutic value in medicine. However, molecular mechanisms of sauchinone were also described in the present review in order to know their biological significance in different kinds of human complications.
Discussion
The scientific evidence in this article demonstrates the medicinal importance and the molecular mechanisms involved in the pharmacological activities of sauchinone in medicine. However, detailed preclinical and clinical data are still needed in scientific research to declare the therapeutic efficacy of sauchinone against human diseases.
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