{"title":"在内镜超声引导下进行胆囊引流术后，通过腔隙贴合金属支架进行口周胆囊镜引导介入治疗：猪模型概念验证研究","authors":"Naminatsu Takahara MD, PhD , Yousuke Nakai MD, PhD , Tatsuya Sato MD, PhD , Ryunosuke Hakuta MD, PhD , Hiroki Oyama MD, PhD , Kensaku Noguchi MD, PhD , Tatsunori Suzuki MD, PhD , Kazunaga Ishigaki MD, PhD , Tomotaka Saito MD, PhD , Tsuyoshi Hamada MD, MPH, PhD , Mitsuhiro Fujishiro MD, PhD","doi":"10.1016/j.igie.2024.07.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Aims</h3><div>EUS-guided gallbladder drainage (EUS-GBD) using a lumen-apposing metal stent (LAMS), originally developed as drainage for cholecystitis, enables endoscopic access into the gallbladder lumen. However, few studies have investigated the feasibility of peroral cholecystoscopy (POCCS)-guided interventions through a LAMS.</div></div><div><h3>Methods</h3><div>EUS-GBD using a LAMS followed by POCCS-guided interventions were performed in 4 swine. Technical success, safety, and feasibility of POCCS visualization and POCCS-guided biopsy sampling and mucosal resection through the LAMS immediately and 3 weeks after EUS-GBD were investigated. Additionally, all specimens including necropsy were pathologically evaluated.</div></div><div><h3>Results</h3><div>POCCS and target biopsy sampling were successful through the LAMS in all swine immediately after EUS-GBD, without any adverse events. POCCS-guided biopsy sampling and mucosal resection 3 weeks after EUS-GBD were technically feasible and pathologically assessable in all swine. The necropsy specimens displayed hyperplastic and inflammatory changes in the gallbladder and nearby organs after 3 weeks of EUS-GBD.</div></div><div><h3>Conclusions</h3><div>POCCS-guided interventions including mucosal resection were technically feasible through a LAMS after EUS-GBD.</div></div>","PeriodicalId":100652,"journal":{"name":"iGIE","volume":"3 3","pages":"Pages 352-357"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Peroral cholecystoscopy–guided interventions through a lumen-apposing metal stent after EUS-guided gallbladder drainage: proof-of-concept study in a swine model\",\"authors\":\"Naminatsu Takahara MD, PhD , Yousuke Nakai MD, PhD , Tatsuya Sato MD, PhD , Ryunosuke Hakuta MD, PhD , Hiroki Oyama MD, PhD , Kensaku Noguchi MD, PhD , Tatsunori Suzuki MD, PhD , Kazunaga Ishigaki MD, PhD , Tomotaka Saito MD, PhD , Tsuyoshi Hamada MD, MPH, PhD , Mitsuhiro Fujishiro MD, PhD\",\"doi\":\"10.1016/j.igie.2024.07.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Aims</h3><div>EUS-guided gallbladder drainage (EUS-GBD) using a lumen-apposing metal stent (LAMS), originally developed as drainage for cholecystitis, enables endoscopic access into the gallbladder lumen. However, few studies have investigated the feasibility of peroral cholecystoscopy (POCCS)-guided interventions through a LAMS.</div></div><div><h3>Methods</h3><div>EUS-GBD using a LAMS followed by POCCS-guided interventions were performed in 4 swine. Technical success, safety, and feasibility of POCCS visualization and POCCS-guided biopsy sampling and mucosal resection through the LAMS immediately and 3 weeks after EUS-GBD were investigated. Additionally, all specimens including necropsy were pathologically evaluated.</div></div><div><h3>Results</h3><div>POCCS and target biopsy sampling were successful through the LAMS in all swine immediately after EUS-GBD, without any adverse events. POCCS-guided biopsy sampling and mucosal resection 3 weeks after EUS-GBD were technically feasible and pathologically assessable in all swine. The necropsy specimens displayed hyperplastic and inflammatory changes in the gallbladder and nearby organs after 3 weeks of EUS-GBD.</div></div><div><h3>Conclusions</h3><div>POCCS-guided interventions including mucosal resection were technically feasible through a LAMS after EUS-GBD.</div></div>\",\"PeriodicalId\":100652,\"journal\":{\"name\":\"iGIE\",\"volume\":\"3 3\",\"pages\":\"Pages 352-357\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"iGIE\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2949708624000980\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"iGIE","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2949708624000980","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Peroral cholecystoscopy–guided interventions through a lumen-apposing metal stent after EUS-guided gallbladder drainage: proof-of-concept study in a swine model
Background and Aims
EUS-guided gallbladder drainage (EUS-GBD) using a lumen-apposing metal stent (LAMS), originally developed as drainage for cholecystitis, enables endoscopic access into the gallbladder lumen. However, few studies have investigated the feasibility of peroral cholecystoscopy (POCCS)-guided interventions through a LAMS.
Methods
EUS-GBD using a LAMS followed by POCCS-guided interventions were performed in 4 swine. Technical success, safety, and feasibility of POCCS visualization and POCCS-guided biopsy sampling and mucosal resection through the LAMS immediately and 3 weeks after EUS-GBD were investigated. Additionally, all specimens including necropsy were pathologically evaluated.
Results
POCCS and target biopsy sampling were successful through the LAMS in all swine immediately after EUS-GBD, without any adverse events. POCCS-guided biopsy sampling and mucosal resection 3 weeks after EUS-GBD were technically feasible and pathologically assessable in all swine. The necropsy specimens displayed hyperplastic and inflammatory changes in the gallbladder and nearby organs after 3 weeks of EUS-GBD.
Conclusions
POCCS-guided interventions including mucosal resection were technically feasible through a LAMS after EUS-GBD.
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