尼日利亚动脉粥样硬化性心血管疾病患者的卵磷脂-胆固醇酰基转移酶和副氧合酶-1水平

IF 1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

African Journal of Laboratory Medicine Pub Date : 2024-07-17 DOI:10.4102/ajlm.v13i1.2286

Promise C. Nwaejigh, M. O. Ebesunun, O. Oladimeji

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引用次数: 0

摘要

背景：最近有证据表明，在不同人群中，血浆卵磷脂胆固醇酰基转移酶（LCAT）和副氧自由基酶-1（PON-1）水平的变化与过早发生动脉粥样硬化性心血管疾病（ASCVD）的风险增加有关。然而，在尼日利亚和撒哈拉以南非洲进行的相关研究却很少：本研究评估了血浆 LCAT 和 PON-1 水平降低与 ASCVD 风险增加之间的关系，以及它们作为 ASCVD 生物标志物的潜力：这项横断面病例对照研究随机选取了2022年3月至2023年3月期间尼日利亚拉各斯市伊科贾的拉各斯州立大学教学医院的动脉粥样硬化性心血管疾病患者和健康对照者。血浆 LCAT 和 PON-1 采用夹心酶联免疫吸附法测定，血脂概况采用分光光度法测量：结果：共有 153 名 ASCVD 患者（平均年龄：52.92 ± 10.24 岁）和 50 名健康对照者（平均年龄：46.96 ± 11.05 岁）参与了分析。与对照组相比，平均体重、臀围、腰围、腰臀比、体重指数、舒张压和收缩压（均 p ≤ 0.001）以及脉搏（p = 0.003）均有明显增加。血浆总胆固醇、甘油三酯、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇的平均值也出现了统计学意义上的明显增加（均 p ≤ 0.001）。相比之下，血浆高密度脂蛋白胆固醇、LCAT 和 PON-1 的平均值（p ≤ 0.001）与对照组相比明显降低：结论：本研究提供的支持性证据表明，血浆 LCAT 和 PON-1 的变化可能使人过早出现 ASCVD 风险：本研究的启示：血浆LCAT和PON-1可作为独立的标志物，或作为其他已确定的心血管疾病标志物的补充，在ASCVD风险不明确时进行鉴别。

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Lecithin-cholesterol acyltransferase and paraoxonase-1 levels in atherosclerotic cardiovascular disease patients in Nigeria

Background: Recent evidence has linked changes in plasma lecithin-cholesterol acyltransferase (LCAT) and paraoxonase-1 (PON-1) levels with increased risk for development of premature atherosclerotic cardiovascular disease (ASCVD) in different populations. However, studies on this in Nigeria and sub-Saharan Africa are scarce.Objective: This study assessed the association between reduced plasma LCAT and PON-1 levels and an increased risk of ASCVD, and their potential as biomarkers for ASCVD.Methods: Atherosclerotic cardiovascular disease patients and healthy controls were randomly selected for this cross-sectional case-control study from the Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria, between March 2022 and March 2023. Plasma LCAT and PON-1 were determined by sandwich enzyme-linked immunosorbent assay, while the lipid profile was measured by spectrophotometry.Results: A total of 153 ASCVD patients (mean age: 52.92 ± 10.24 years) and 50 healthy controls (mean age: 46.96 ± 11.05 years) were included in the analyses. Stastistically significant increases were observed in the mean body weight, hip circumference, waist circumference, waist-to-hip ratio, body mass index, diastolic and systolic blood pressure (all p ≤ 0.001), and pulse rate (p = 0.003) compared to the control values. Statistically significant increases were also observed in the mean plasma total cholesterol, triglycerides, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (all p ≤ 0.001). In contrast, the mean plasma high-density lipoprotein cholesterol, LCAT, and PON-1 (p ≤ 0.001) were notably reduced compared to the control values.Conclusion: The present study provides supportive evidence that changes in plasma LCAT and PON-1 could predispose individuals to risk of premature ASCVD.What this study adds: Plasma LCAT and PON-1 may serve as independent markers or complement other established cardiovascular disease markers to discriminate the risk of ASCVD when it is unclear.

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来源期刊

African Journal of Laboratory Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

12 weeks

期刊介绍： The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.