碳水化合物吸收不良综合征在轮状病毒腹泻发病机制中的作用(文献综述)

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
O. Usachova, N. Vorobiova, E. Silina, T. B. Matvieieva
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引用次数: 0

摘要

目的--通过对文献综述和实证研究的综合分析,总结有关轮状病毒感染儿童腹泻综合征发病机制的文献数据,并确定碳水化合物吸收不良综合征在其中的作用。轮状病毒感染(RVI)仍然是导致五岁以下儿童严重脱水性肠胃炎的主要原因。轮状病毒肠胃炎最重要的致病环节之一是碳水化合物吸收不良综合征诱发的渗透性腹泻。碳水化合物吸收不良综合征在 67.0-98.3 % 的轮状病毒胃肠炎患儿中存在。其实验室表现(粪便中碳水化合物和乳糖含量的增加)从发病的第一天起就可以观察到,第五天至第七天的指标最高。绝大多数 RVI 患儿都会出现碳水化合物吸收不良综合征,发病第五天至第七天时症状最为严重,这主要是由于乳糖酶缺乏所致。碳水化合物吸收不良综合征的严重程度可能受伴随病理条件的影响,这些病理条件导致小肠中二糖酶活性降低,以及肠道微生物群的代谢活性降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of carbohydrate malabsorption syndrome in the pathogenesis of rotavirus diarrhea (a literature review)
The aim – to summarize literature data on the pathogenetic mechanisms of the diarrheal syndrome development in children with rotavirus infection and to determine the role of carbohydrate malabsorption syndrome in it through a complex analysis of literature reviews and empirical studies. Rotavirus infection (RVI) remains the main cause of severe dehydrating gastroenteritis in children under five years of age. One of the most important pathogenetic links of rotavirus gastroenteritis is the development of osmotic diarrhea induced by carbohydrate malabsorption syndrome. Its development is associated with disaccharidase insufficiency and impaired absorption of monosaccharides in the small intestine. Carbohydrate malabsorption syndrome is found in 67.0–98.3 % of children with RVI. Its laboratory manifestations (an increase in levels of fecal carbohydrates and lactose) are observed starting from the first days of the disease, and the maximum indicators are recorded in the period from the fifth to the seventh day. Conclusions. Carbohydrate malabsorption syndrome is observed in the absolute majority of children with RVI, and its maximum severity is noted from the fifth to the seventh day of the disease, being realized mainly due to lactase deficiency. The severity of carbohydrate malabsorption syndrome can be influenced by concomitant pathological conditions, that lead to a decrease in the activity of disaccharidases in the small intestine, and the metabolic activity of the intestinal microbiota.
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来源期刊
Zaporozhye Medical Journal
Zaporozhye Medical Journal MEDICINE, GENERAL & INTERNAL-
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