异体干细胞捐献者的生活方式与捐献的 CD34+ 和 CD3+ 细胞数量之间的关系

Leila Sayadi, Saeed Mohammadi, Parivash Aminian
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引用次数: 0

摘要

背景:造血干细胞移植(HSCT)被认为是许多危及生命的疾病的最后治疗方案。捐献细胞的数量会影响移植的成功率。本研究试图调查异体干细胞捐献者促进健康的生活方式与捐献的 CD34+ 和 CD3+ 细胞数量之间的关系。材料与方法:本研究是一项描述性相关研究,共有 100 名外周血干细胞捐献者参加。研究人员向参与者发放了人口统计学表格和健康促进生活方式档案-II问卷,然后开始进行细胞分离。之后,记录参与者的 CD34 + 和 CD3 + 细胞计数结果以及其他临床参数。收集的数据采用描述性和分析性统计方法进行分析。结果显示 结果显示,造血干细胞捐献者健康促进生活方式档案总分的平均值为(2.876±0.461)分。促进健康生活方式评分与 CD34+、CD3+ 细胞数量和 CD3+/CD34+ 比率之间无明显关系。供体体重与 CD34+ 细胞数(P < 0.001)和 CD3+ 细胞数(P = 0.001)之间存在明显的正相关。女性和男性的 CD34+ 细胞数量存在显著差异(P = 0.009)。结论生活方式对 CD3+/CD34+ 细胞数量无明显影响。此外,男性的 CD34+ 细胞数量明显高于女性,因此造血干细胞移植手术应优先选择男性捐献者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Relationship between the Lifestyle of the Allogeneic Stem Cell Donors and the Number of Donated CD34+ and CD3+ Cells
Background: Hematopoietic stem cell transplantation (HSCT) is considered as the last treatment option in many life-threatening diseases. The number of donated cells can affect transplantation success. This study attempted to investigate the relationship between the health-promoting lifestyle of allogeneic stem cell donors and the number of donated CD34+ and CD3+ cells. Materials and Methods: The study was a descriptive correlational study in which 100 peripheral blood stem cells donors participated. A demographic form and health-promoting lifestyle profile-II questionnaire were distributed to participants, and then cell separation was started. Afterward, the results of CD34 + and CD3 + cell counts, as well as other clinical parameters of the participants, were recorded. The collected data were analyzed by descriptive and analytical statistical methods. Results:  The results showed that the mean total health-promoting lifestyle profile score for hematopoietic stem cell donors was 2.876±0.461. There was no significant relationship between the health- promoting lifestyle score and the number of CD34+, CD3+ cells and CD3+/CD34+ ratio. A positive and significant correlation was found between the weight of the donors and the number of CD34+ (P < 0.001) and CD3+ cells (P = 0.001). The number of CD34+ cells was significantly different between women and men (P = 0.009). Conclusion: Lifestyle had no significant effect on the number of CD3+/CD34+ cells. Moreover, the number of CD34+ cells was significantly higher in men, so males should be preferentially recruited as donors for the HSCT procedure.
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