{"title":"阿菲康坦通过改变肌动蛋白的相互作用降低心脏收缩力","authors":"Farid Moussavi-Harami, Michael Regnier","doi":"10.1038/s44161-024-00503-2","DOIUrl":null,"url":null,"abstract":"Aficamten, a small-molecule myosin inhibitor, binds to the catalytic domain of cardiac myosin and reduces contraction by stabilizing the initial weak interaction between myosin and actin.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 8","pages":"893-894"},"PeriodicalIF":9.4000,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aficamten reduces cardiac contractility by modifying the actomyosin interaction\",\"authors\":\"Farid Moussavi-Harami, Michael Regnier\",\"doi\":\"10.1038/s44161-024-00503-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aficamten, a small-molecule myosin inhibitor, binds to the catalytic domain of cardiac myosin and reduces contraction by stabilizing the initial weak interaction between myosin and actin.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"3 8\",\"pages\":\"893-894\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00503-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00503-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Aficamten reduces cardiac contractility by modifying the actomyosin interaction
Aficamten, a small-molecule myosin inhibitor, binds to the catalytic domain of cardiac myosin and reduces contraction by stabilizing the initial weak interaction between myosin and actin.
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