尼日利亚贝宁市一家三级医院从临床标本中分离出的肺炎克雷伯氏菌的多重抗生素耐药性指数

H. Ogefere, MO Idoko
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引用次数: 0

摘要

背景:肺炎克雷伯氏菌是一种胃肠道共生菌,但与医院和社区感染有关。在这项调查中,对从贝宁市一家三级医院病人的几份临床标本中分离出的肺炎克雷伯菌进行了多重抗生素耐药性(MAR)指数评估。研究方法从该医院的住院病人和门诊病人中总共分离出 100 例肺炎克雷伯菌临床样本。采用常规微生物学技术对分离株进行鉴定。进行抗生素药敏试验并计算 MAR 指数。结果显示药敏试验表明,肺炎克氏菌对多种药物具有高度耐药性,共有 24 个分离株对 12 种抗生素具有耐药性。MAR 指数在 0.42 至 1.00 之间,平均值为 0.7994。从住院患者临床样本中分离出的肺炎克雷伯菌的MAR指数为0.82,高于门诊患者的MAR指数(0.74)。结论这些发现是一个重大的公共卫生问题。必须齐心协力,强调抗菌药物管理,以缓解这一问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multiple antibiotic resistance index of Klebsiella pneumoniae isolated from clinical specimens in a tertiary hospital in Benin City, Nigeria
Background: Klebsiella pneumoniae is a commensal of the gastrointestinal tract but has been associated with hospital associated- and community infections. In this investigation, K. pneumoniae that was isolated from several clinical specimens of patients at a tertiary hospital in Benin City was evaluated for its multiple antibiotic resistance (MAR) index.  Methods: A total of 100 clinical isolates of K. pneumoniae from the hospital’s inpatients and outpatients were employed. By using conventional microbiological techniques, isolates were identified. Antibiotic susceptibility testing was carried out and MAR index was calculated.  Results: The susceptibility test showed that K. pneumoniae exhibited high level of multidrug resistance with a total of 24 isolates resistant to the 12 antibiotics tested. The MAR index ranged from 0.42 to 1.00 with the mean value of 0.7994. The K. pneumoniae isolates from clinical specimens of inpatients showed a higher MAR index of 0.82 than that of outpatients (0.74).  Conclusion: These findings present a major public health concern. Concerted efforts that emphasize antimicrobial stewardship must be put in place to mitigate this problem.
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